N-(2-naphthyl)-3-nitroanthranilic acid

Base Information

• Chemical Name: N-(2-naphthyl)-3-nitroanthranilic acid
• CAS No.: 106987-79-5
• Molecular Formula: C₁₇H₁₂N₂O₄
• Molecular Weight: 308.293
• Mol file: 106987-79-5.mol

Synonyms:N-(2-naphthyl)-3-nitroanthranilic acid

Chemical Property of N-(2-naphthyl)-3-nitroanthranilic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-(2-naphthyl)-3-nitroanthranilic acid

There total 3 articles about N-(2-naphthyl)-3-nitroanthranilic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.6%

→ N-(2-naphthyl)-3-nitroanthranilic acid (106987-79-5)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; for 1h; Reflux;

Reference yield: 62.0%

2-bromo-3-nitro-benzoic acid (573-54-6) + naphthalen-2-ylamine (91-59-8) → N-(2-naphthyl)-3-nitroanthranilic acid (106987-79-5)

Guidance literature:

With N-ethylmorpholine;; copper; copper(l) chloride; In various solvent(s); at 70 - 80 ℃; for 15h;

DOI:10.1021/jm00388a017

Reference yield:

naphthalen-2-ylamine (91-59-8) → N-(2-naphthyl)-3-nitroanthranilic acid (106987-79-5)

Guidance literature:

With copper; potassium carbonate; butan-1-ol;

DOI:10.1021/jo01159a011

upstream raw materials:

2-bromo-3-nitro-benzoic acid

naphthalen-2-ylamine

Downstream raw materials:

3-amino-2-[2]naphthylamino-benzoic acid

Refernces

• 1、 Rewcastle,Denny,Baguley. "Potential antitumor agents. 51. Synthesis and antitumor activity of substituted phenazine-1-carboxamides". . p. 843 - 851. Retrieved 2007/10/02.