3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-(bis(4-fluorophenyl)methyl)piperazine-1-carbodithioate

Base Information

• Chemical Name: 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-(bis(4-fluorophenyl)methyl)piperazine-1-carbodithioate
• CAS No.: 1259017-55-4
• Molecular Formula: C₄₃H₃₉ClF₃N₅O₃S₂
• Molecular Weight: 830.395
• Mol file: 1259017-55-4.mol

Synonyms:3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-(bis(4-fluorophenyl)methyl)piperazine-1-carbodithioate

Chemical Property of 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-(bis(4-fluorophenyl)methyl)piperazine-1-carbodithioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-(bis(4-fluorophenyl)methyl)piperazine-1-carbodithioate

There total 8 articles about 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-(bis(4-fluorophenyl)methyl)piperazine-1-carbodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

carbon disulfide (75-15-0,12122-00-8) + N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)-7-methoxyquina-zolin-4-amine (1259017-73-6) + 1-(4-fluorophenyl)methyl-piperazine (27469-60-9) → 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-(bis(4-fluorophenyl)methyl)piperazine-1-carbodithioate (1259017-55-4)

Guidance literature:

1-(4-fluorophenyl)methyl-piperazine; With potassium phosphate; In N,N-dimethyl-formamide; for 0.25h;

carbon disulfide; In N,N-dimethyl-formamide; for 0.5h;

N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)-7-methoxyquina-zolin-4-amine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.04.096

Reference yield:

6-(3-chloropropoxy)-7-methoxyquinazolin-4-ol (574738-93-5) → 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-(bis(4-fluorophenyl)methyl)piperazine-1-carbodithioate (1259017-55-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 3 h / Reflux

2.1: triethylamine / isopropyl alcohol / 3 h / Reflux

3.1: potassium phosphate / N,N-dimethyl-formamide / 0.25 h

3.2: 0.5 h

With potassium phosphate; thionyl chloride; triethylamine; N,N-dimethyl-formamide; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2011.04.096

Reference yield:

6-(3-chloropropoxy)-4-chloro-7-methoxyquinazoline (692059-41-9) → 3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazolin-6-yloxy)propyl 4-(bis(4-fluorophenyl)methyl)piperazine-1-carbodithioate (1259017-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / isopropyl alcohol / 3 h / Reflux

2.1: potassium phosphate / N,N-dimethyl-formamide / 0.25 h

2.2: 0.5 h

With potassium phosphate; triethylamine; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmcl.2011.04.096

upstream raw materials:

carbon disulfide

N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-(3-chloropropoxy)-7-methoxyquina-zolin-4-amine

1-(4-fluorophenyl)methyl-piperazine

6-(3-chloropropoxy)-4-chloro-7-methoxyquinazoline

Refernces