Technology Process of 1-(2-hydroxy-5-methoxy-3,4,6-trimethylphenyl)ethanone
There total 5 articles about 1-(2-hydroxy-5-methoxy-3,4,6-trimethylphenyl)ethanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
titanium tetrachloride;
In
dichloromethane;
at 0 ℃;
for 72h;
Reflux;
DOI:10.1002/ejoc.201402240
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine / dichloromethane / 18 h / 0 - 20 °C
2: titanium tetrachloride / dichloromethane / 72 h / 0 °C / Reflux
With
pyridine; titanium tetrachloride;
In
dichloromethane;
2: |Fries Phenol Ester Rearrangement;
DOI:10.1002/ejoc.201402240
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridine / dichloromethane / 18 h / 0 - 20 °C
2.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 0 °C
2.2: 18 h / 20 °C
3.1: potassium hydroxide / N,N-dimethyl-formamide; water / 4 h / 0 - 20 °C
4.1: pyridine / dichloromethane / 18 h / 0 - 20 °C
5.1: titanium tetrachloride / dichloromethane / 72 h / 0 °C / Reflux
With
pyridine; titanium tetrachloride; sodium hydride; potassium hydroxide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
5.1: |Fries Phenol Ester Rearrangement;
DOI:10.1002/ejoc.201402240
