N³-benzyl-4-methylbenzimidazole

Base Information

• Chemical Name: N³-benzyl-4-methylbenzimidazole
• CAS No.: 73902-60-0
• Molecular Formula: C₁₅H₁₄N₂
• Molecular Weight: 222.29
• Mol file: 73902-60-0.mol

Synonyms:N³-benzyl-4-methylbenzimidazole

Chemical Property of N³-benzyl-4-methylbenzimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N³-benzyl-4-methylbenzimidazole

There total 3 articles about N³-benzyl-4-methylbenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-Benzyl-3-(2-cyano-1-methyl-ethyl)-7-methyl-3H-benzoimidazol-1-ium; bromide → N3-benzyl-4-methylbenzimidazole (73902-60-0)

Guidance literature:

With sodium hydroxide; In water; for 0.666667h; Ambient temperature;

DOI:10.1055/s-1995-4054

Reference yield:

4-methylbenzimidazole (4887-83-6) + benzyl chloride (100-44-7) → N3-benzyl-4-methylbenzimidazole (73902-60-0) + N1-benzyl-4-methylbenzimidazole (73902-59-7)

Guidance literature:

With sodium methylate; Rate constant; Product distribution; 1.) MeOH; 2.) DMF, 30 deg C, 1 h; reaction of various benzimidazoles with several alkylating agent;

DOI:10.1016/S0040-4020(01)80708-0

Reference yield:

→ N3-benzyl-4-methylbenzimidazole (73902-60-0)

Guidance literature:

4-Methylbenzimidazol, Benzylchlorid / Na-acetat;

upstream raw materials:

4-methylbenzimidazole

benzyl chloride

Downstream raw materials:

4-methylbenzimidazole

Refernces

• 1、 Haque, M. Rezaul,Rasmussen, Malcolm. "Ambident heterocyclic reactivity: Alkylation of 2-substituted-4-methylbenzimidazoles". . p. 5535 - 5554. Retrieved 2007/10/02.