ethyl2-methylquinoline-6-carboxylate

Base Information

• Chemical Name: ethyl2-methylquinoline-6-carboxylate
• CAS No.: 855763-77-8
• Molecular Formula: C₁₃H₁₃NO₂
• Molecular Weight: 215.252
• Hs Code.: 2933499090
• Mol file: 855763-77-8.mol

Synonyms:Ethyl2-methylquinoline-6-carboxylate;2-Methylquinoline-6-carboxylic acid ethyl ester;Ethyl4-hydroxy-2-methylquinoline-6-carboxylate;

Chemical Property of ethyl2-methylquinoline-6-carboxylate

Chemical Property:

• Vapor Pressure: 0.000128mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 334.4 °C at 760 mmHg
• PKA: 4.95±0.43(Predicted)
• Flash Point: 156.1 °C
• PSA: 39.19000
• Density: 1.148 g/cm³
• LogP: 2.71990
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Methylquinoline-6-carboxylicacidethylester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl2-methylquinoline-6-carboxylate

There total 3 articles about ethyl2-methylquinoline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethanol (64-17-5) + p-aminoethylbenzoate (94-09-7) → ethyl 2-methylquinoline-6-carboxylate (855763-77-8)

Guidance literature:

With 2,4,6-trimethyl-pyridine; oxygen; palladium diacetate; trifluoroacetic acid; at 150 ℃; for 36h; Schlenk technique;

DOI:10.1021/acs.joc.6b03064

Reference yield:

quinaldine-6-carboxylic acid (635-80-3) → ethyl 2-methylquinoline-6-carboxylate (855763-77-8)

Guidance literature:

With hydrogenchloride;

Reference yield:

→ ethyl 2-methylquinoline-6-carboxylate (855763-77-8)

Guidance literature:

9;

upstream raw materials:

quinaldine-6-carboxylic acid

ethanol

p-aminoethylbenzoate

Downstream raw materials:

2-methylquinoline-6-carboxamide

Refernces

• 1、 -. "Preparation method of quinoline derivative". Paragraph 0101; 0102. . Retrieved 2017/06/02.