Multi-step reaction with 8 steps
1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / diethyl ether; cyclohexane / 1.67 h / -78 °C / Inert atmosphere; Cooling with acetone-dry ice
1.2: 1 h / -78 - 20 °C / Inert atmosphere
2.1: N-Bromosuccinimide / dichloromethane / 20 °C / Inert atmosphere
3.1: trifluoroacetic acid / 16 h / 20 °C / Inert atmosphere
4.1: manganese(IV) oxide / tetrahydrofuran / 20 °C / Inert atmosphere
5.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0.17 h / Cooling with ice; Molecular sieve; Inert atmosphere
5.2: 20 °C / Inert atmosphere; Cooling with ice; Molecular sieve
5.3: 0 - 20 °C / Inert atmosphere
6.1: dmap / dichloromethane / 20 °C / Inert atmosphere
7.1: urea hydrogen peroxide adduct; trifluoroacetic anhydride / acetonitrile / 0 - 20 °C / Inert atmosphere
8.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 20 - 120 °C / Heating; Inert atmosphere; Microwave irradiation
8.3: 20 °C
With
dmap; manganese(IV) oxide; N-Bromosuccinimide; N,N,N,N,-tetramethylethylenediamine; trimethylsilyl trifluoromethanesulfonate; sec.-butyllithium; urea hydrogen peroxide adduct; potassium carbonate; trifluoroacetic acid; trifluoroacetic anhydride;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; cyclohexane; water; acetonitrile;