N-benzyl-2-(5-fluoro-1-methyl-1H-indol-3-yl)acetamide

Base Information

• Chemical Name: N-benzyl-2-(5-fluoro-1-methyl-1H-indol-3-yl)acetamide
• CAS No.: 1383933-33-2
• Molecular Formula: C₁₈H₁₇FN₂O
• Molecular Weight: 296.344
• Mol file: 1383933-33-2.mol

Synonyms:N-benzyl-2-(5-fluoro-1-methyl-1H-indol-3-yl)acetamide

Chemical Property of N-benzyl-2-(5-fluoro-1-methyl-1H-indol-3-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-2-(5-fluoro-1-methyl-1H-indol-3-yl)acetamide

There total 4 articles about N-benzyl-2-(5-fluoro-1-methyl-1H-indol-3-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(5-fluoro-1H-indol-3-yl)-2-oxoacetic acid (913320-96-4) → N-benzyl-2-(5-fluoro-1-methyl-1H-indol-3-yl)acetamide (1383933-33-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium acetate; hydrazine hydrate / ethyl methyl ether

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

3: tetrabutylammonium sulfate; potassium hydroxide / dichloromethane; water

With sodium acetate; hydrazine hydrate; tetrabutylammonium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In ethyl methyl ether; dichloromethane; water;

DOI:10.1021/ja305100g

Reference yield:

(5-fluoroindol-3-yl)acetic acid (443-73-2) → N-benzyl-2-(5-fluoro-1-methyl-1H-indol-3-yl)acetamide (1383933-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

2: tetrabutylammonium sulfate; potassium hydroxide / dichloromethane; water

With tetrabutylammonium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In dichloromethane; water;

DOI:10.1021/ja305100g

Reference yield:

5-fluoro-1H-indole (399-52-0) → N-benzyl-2-(5-fluoro-1-methyl-1H-indol-3-yl)acetamide (1383933-33-2)

Guidance literature:

Multi-step reaction with 4 steps

1: diethyl ether

2: sodium acetate; hydrazine hydrate / ethyl methyl ether

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

4: tetrabutylammonium sulfate; potassium hydroxide / dichloromethane; water

With sodium acetate; hydrazine hydrate; tetrabutylammonium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In diethyl ether; ethyl methyl ether; dichloromethane; water;

DOI:10.1021/ja305100g

upstream raw materials:

5-fluoro-1H-indole

2-(5-fluoro-1H-indol-3-yl)-2-oxoacetic acid

C₁₇H₁₅FN₂O

methyl iodide

Downstream raw materials:

(3aS,8aR)-1-benzyl-5-fluoro-8-methyl-3a-phenyl-3,3a,8,8a-tetrahydropyrrolo[2,3-b]indol-2(1H)-one

Refernces