benzoic acid, 3-(acetyloxy)-, ethyl ester

Base Information

• Chemical Name: benzoic acid, 3-(acetyloxy)-, ethyl ester
• CAS No.: 68191-25-3
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.214
• Mol file: 68191-25-3.mol

Synonyms:m-EtO₂CC₆H₄OAc

Chemical Property of benzoic acid, 3-(acetyloxy)-, ethyl ester

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzoic acid, 3-(acetyloxy)-, ethyl ester

There total 7 articles about benzoic acid, 3-(acetyloxy)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzoic acid ethyl ester (93-89-0,99341-95-4) + acetic anhydride (108-24-7) → ethyl acetylsalicylate (529-68-0) + ethyl 4-acetoxybenzoate (13031-45-3) + m-EtO2CC6H4OAc (68191-25-3)

Guidance literature:

acetic anhydride; With pyridine; iodomesitylene diacetate; palladium diacetate; In acetic acid; at 20 ℃; for 0.0166667h;

benzoic acid ethyl ester; In acetic acid; at 100 ℃; for 21h;

DOI:10.1002/anie.201103327

Reference yield:

[bis(acetoxy)iodo]benzene (3240-34-4) + benzoic acid ethyl ester (93-89-0,99341-95-4) → ethyl acetylsalicylate (529-68-0) + ethyl 4-acetoxybenzoate (13031-45-3) + m-EtO2CC6H4OAc (68191-25-3)

Guidance literature:

[bis(acetoxy)iodo]benzene; With 6-fluoropyridine-2-carboxylic acid; palladium diacetate; acetic anhydride; acetic acid; at 20 ℃; for 0.00416667h;

benzoic acid ethyl ester; at 100 ℃; for 14h; Overall yield = 64 %Chromat.; Sealed tube;

DOI:10.1002/cctc.201600757

Reference yield:

[bis(acetoxy)iodo]benzene (3240-34-4) + benzoic acid ethyl ester (93-89-0,99341-95-4) + acetic anhydride (108-24-7) → ethyl acetylsalicylate (529-68-0) + ethyl 4-acetoxybenzoate (13031-45-3) + m-EtO2CC6H4OAc (68191-25-3)

Guidance literature:

With (C₅H₂N(C₆H₅)3C₅H₃N)2⁽²⁺⁾*2BF₄^(1-)=(C₅H₂N(C₆H₅)3C₅H₃N)2(BF₄)2; palladium diacetate; acetic acid; at 100 ℃; for 48h;

DOI:10.1002/anie.201002351

upstream raw materials:

Ketene

diethyl ether

ethyl-3-hydroxybenzoate

acetic anhydride

Downstream raw materials:

C₁₁H₉NO₃

Refernces

• 1、 Emmert, Marion H.,Cook, Amanda K.,Xie, Yushu J.,Sanford, Melanie S.. "Remarkably high reactivity of Pd(OAc)2/pyridine catalysts: Nondirected C-H oxygenation of arenes". supporting information; experimental part. p. 9409 - 9412. Retrieved 2011/11/07.