2-(6H-indolo[2,3-b]quinoxalin-6-yl)acetohydrazide

Base Information

• Chemical Name: 2-(6H-indolo[2,3-b]quinoxalin-6-yl)acetohydrazide
• CAS No.: 116989-58-3
• Molecular Formula: C₁₆H₁₃N₅O
• Molecular Weight: 291.312
• Mol file: 116989-58-3.mol

Synonyms:6-(hydrazinocarbonylmethyl)-6H-indolo[2,3-b]quinoxaline

Chemical Property of 2-(6H-indolo[2,3-b]quinoxalin-6-yl)acetohydrazide

Chemical Property:

Purity/Quality:

2-(6H-INDOLO[2,3-B]QUINOXALIN-6-YL)ACETOHYDRAZIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(6H-indolo[2,3-b]quinoxalin-6-yl)acetohydrazide

There total 7 articles about 2-(6H-indolo[2,3-b]quinoxalin-6-yl)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 2-(6H-indolo[2,3-b]quinoxaline-6-yl)acetate (25681-03-2) → 6-(hydrazinocarbonylmethyl)-6H-indolo[2,3-b]quinoxaline (116989-58-3)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 0.0333333 - 0.0833333h; under 258.581 - 310.297 Torr; Sealed tube; Microwave irradiation;

DOI:10.1002/jhet.2272

Reference yield:

indophenazine (243-59-4,84055-81-2) → 6-(hydrazinocarbonylmethyl)-6H-indolo[2,3-b]quinoxaline (116989-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / potassium carbonate; sodium iodide / dimethylformamide / 0.1 h / microwave irradiation

2: 84 percent / hydrazine hydrate / ethanol / 0.04 h / microwave irradiation

With potassium carbonate; hydrazine hydrate; sodium iodide; In ethanol; N,N-dimethyl-formamide;

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → 6-(hydrazinocarbonylmethyl)-6H-indolo[2,3-b]quinoxaline (116989-58-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 93 percent / acetic acid / 0.03 h / microwave irradiation

2: 53 percent / potassium carbonate; sodium iodide / dimethylformamide / 0.1 h / microwave irradiation

3: 84 percent / hydrazine hydrate / ethanol / 0.04 h / microwave irradiation

With potassium carbonate; hydrazine hydrate; acetic acid; sodium iodide; In ethanol; N,N-dimethyl-formamide;

upstream raw materials:

ethyl 2-(6H-indolo[2,3-b]quinoxaline-6-yl)acetate

indophenazine

(1-ethoxycarbonylmethyl)isatin

indole-2,3-dione

Downstream raw materials:

C₃₃H₂₂ClN₅O₃

C₃₃H₂₃N₅O₄

C₃₄H₂₅N₅O₅

C₃₃H₂₂N₆O₅

Refernces

• 1、 Manna, Kuntal,Agrawal, Yadvendra K.. "Microwave assisted synthesis of new indophenazine 1,3,5-trisubstruted pyrazoline derivatives of benzofuran and their antimicrobial activity". supporting information; experimental part. p. 2688 - 2692. Retrieved 2010/03/24.