7-(benzyloxy)-5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-6-yl 2-hydroxyacetate

Base Information

• Chemical Name: 7-(benzyloxy)-5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-6-yl 2-hydroxyacetate
• CAS No.: 1357354-99-4
• Molecular Formula: C₂₄H₁₈O₇
• Molecular Weight: 418.403
• Mol file: 1357354-99-4.mol

Synonyms:7-(benzyloxy)-5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-6-yl 2-hydroxyacetate

Chemical Property of 7-(benzyloxy)-5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-6-yl 2-hydroxyacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-(benzyloxy)-5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-6-yl 2-hydroxyacetate

There total 4 articles about 7-(benzyloxy)-5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-6-yl 2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

glycolic Acid (79-14-1) + 7-(benzyloxy)-5,6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one (5928-35-8) → 7-(benzyloxy)-5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-6-yl 2-hydroxyacetate (1357354-99-4)

Guidance literature:

glycolic Acid; 7-(benzyloxy)-5,6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃; for 4.5h;

With dmap; In dichloromethane; at 25 ℃; for 4h;

DOI:10.1002/hlca.201100162

Reference yield:

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one (491-67-8) → 7-(benzyloxy)-5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-6-yl 2-hydroxyacetate (1357354-99-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium acetate / 2 h / 80 °C

2.1: potassium carbonate; potassium iodide / acetone / 8 h / 60 °C / Reflux

3.1: hydrogenchloride / ethanol; water / Heating

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 4.5 h / 0 - 25 °C

4.2: 4 h / 25 °C

With hydrogenchloride; sodium acetate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium iodide; In ethanol; dichloromethane; water; acetone;

DOI:10.1002/hlca.201100162

Reference yield:

4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl triacetate (67047-05-6) → 7-(benzyloxy)-5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-6-yl 2-hydroxyacetate (1357354-99-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / acetone / 8 h / 60 °C / Reflux

2.1: hydrogenchloride / ethanol; water / Heating

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 4.5 h / 0 - 25 °C

3.2: 4 h / 25 °C

With hydrogenchloride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium iodide; In ethanol; dichloromethane; water; acetone;

DOI:10.1002/hlca.201100162

upstream raw materials:

glycolic Acid

7-(benzyloxy)-5,6-dihydroxy-2-phenyl-4H-1-benzopyran-4-one

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl triacetate

Refernces