A 769662

Base Information

• Chemical Name: A 769662
• CAS No.: 844499-71-4
• Molecular Formula: C20H12N2O3S
• Molecular Weight: 360.393
• Hs Code.: 29333990
• Mol file: 844499-71-4.mol

Synonyms:4-Hydroxy-3-(2'-hydroxy-1,1'-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;A 769662;

Chemical Property of A 769662

Chemical Property:

• Boiling Point: 556.6 °C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 290.4 °C
• PSA: 125.35000
• Density: 1.56 g/cm³
• LogP: 4.20648
• Storage Temp.: Store at +4°C
• Solubility.: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml),

Purity/Quality:

99% ^*data from raw suppliers

A-769662 ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Description: A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172. A-769662 specifically activates β1 subunit-containing AMPK heterotrimers, and its effects are independent of kinases upstream of AMPK. A-769662 has been used to stimulate CYP450-mediated fatty acid oxidation, inhibit adipocyte differentiation, explore glucose uptake in skeletal muscle, and promote endothelial cell survival during metabolic stress.
• Uses: A 769662 is an AMP-activated protein kinase (AMPK) activiator. A 769662 selectively activates cardiac AMPK heterotrimeric complexes contg. α2/β1-subunits.

Technology Process of A 769662

There total 1 articles about A 769662 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-hydroxy-3-(2′-hydroxy-[1,1′-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile (844499-71-4)

Guidance literature:

Reference yield:

4-hydroxy-3-(2′-hydroxy-[1,1′-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile (844499-71-4) + ethyl bromoacetate (105-36-2) → {[4'-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)-1,1'-biphenyl-2-yl]oxy}acetic acid

Guidance literature:

4-hydroxy-3-(2′-hydroxy-[1,1′-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile; With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetone; at 20 ℃; for 0.5h;

ethyl bromoacetate; In acetone; at 20 ℃; for 16h;

Reference yield:

4-hydroxy-3-(2′-hydroxy-[1,1′-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile (844499-71-4) → 3-[4-(2-hydroxyphenyl)-phenyl]-4-hydroxy-5-iminomethyl-6-oxo-7H-thieno[2,3-b]-pyridine-6-one (844501-29-7)

Guidance literature:

aluminum nickel; In formic acid; for 24h; Heating / reflux;

Downstream raw materials:

3-[4-(2-hydroxyphenyl)-phenyl]-4-hydroxy-5-iminomethyl-6-oxo-7H-thieno[2,3-b]-pyridine-6-one

Refernces