6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER

Base Information

• Chemical Name: 6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER
• CAS No.: 842136-58-7
• Molecular Formula: C11H15BFNO2
• Molecular Weight: 223.055
• Hs Code.: 2934999090
• Mol file: 842136-58-7.mol

Synonyms:2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;

Chemical Property of 6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER

Chemical Property:

• Vapor Pressure: 0.000994mmHg at 25°C
• Refractive Index: 1.477
• Boiling Point: 312.1 °C at 760 mmHg
• Flash Point: 142.5 °C
• PSA: 31.35000
• Density: 1.09 g/cm³
• LogP: 1.51990
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%min ^*data from raw suppliers

6-Fluoropyridine-2-boronicacidpinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER

There total 1 articles about 6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-bromo-6-fluoropyridine (144100-07-2) + bis(pinacol)diborane (73183-34-3) → 2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (842136-58-7)

Guidance literature:

With (dppf)2PdCl_2.HCl; potassium acetate; In 1,4-dioxane; at 20 - 115 ℃; for 1h; Inert atmosphere;

Reference yield: 99.0%

2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (842136-58-7) + (6S)-6-[(4-iodobenzyl)oxy]-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-ol (281225-12-5) → (6S)-6-{[4-(6-fluoro-2-pyridinyl)benzyl]oxy}-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (1257425-53-8)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In ethanol; water; toluene; for 1.5h; Inert atmosphere; Reflux;

DOI:10.1021/jm101288t

Reference yield: 88.0%

2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (842136-58-7) + 5-(3-iodo-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-thiadiazol-2-amine (1401348-70-6) → 5-(3-(6-fluoropyridin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(4-methoxybenzyl)-1,3,4-thiadiazol-2-amine (1401348-75-1)

Guidance literature:

With potassium phosphate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); In 1,4-dioxane; water; at 105 ℃; for 0.5h; Microwave irradiation;

upstream raw materials:

2-bromo-6-fluoropyridine

bis(pinacol)diborane

Downstream raw materials:

(6S)-6-{[4-(6-fluoro-2-pyridinyl)benzyl]oxy}-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

N-(3-methylphenyl)-4-(2-(6-fluoropyridin-2-yl)-4-pyridinyl)-1,3-thiazol-2-amine

(R)-3-[5'-chloro-6-(cyclohexylmethylamino)-[2,4,]bipyridinyl-2'-ylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "P2X7 MODULATORS". Paragraph 0531; 0532. . Retrieved 2014/09/30.
• 2、 -. "N-ACYL PYRIDINE BIARYL COMPOUNDS AND THEIR USES". Page/Page column 143-144. . Retrieved 2012/08/08.