2-((dimethylamino)methyl)-N-phenylaniline

Base Information

• Chemical Name: 2-((dimethylamino)methyl)-N-phenylaniline
• CAS No.: 24103-85-3
• Molecular Formula: C₁₅H₁₈N₂
• Molecular Weight: 226.321
• Mol file: 24103-85-3.mol

Synonyms:2-((dimethylamino)methyl)-N-phenylaniline

Chemical Property of 2-((dimethylamino)methyl)-N-phenylaniline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-((dimethylamino)methyl)-N-phenylaniline

There total 8 articles about 2-((dimethylamino)methyl)-N-phenylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N,N-dimethyl-2-(phenylamino)benzamide (935688-11-2) → 2-((dimethylamino)methyl)-N-phenylaniline (24103-85-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 50 ℃; Inert atmosphere;

DOI:10.1021/acs.organomet.6b00384

Reference yield: 69.0%

aniline (62-53-3) + N,N-dimethyl-1-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenyl)methanamine (129636-11-9) → 2-((dimethylamino)methyl)-N-phenylaniline (24103-85-3)

Guidance literature:

With oxygen; copper(II) acetate monohydrate; In acetonitrile; at 80 ℃; for 2h; Reagent/catalyst; chemoselective reaction; Catalytic behavior; Schlenk technique; Molecular sieve;

DOI:10.1021/acs.joc.5b01074

Reference yield: 61.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-Methylaminomethyl-diphenylamin (24103-82-0) → 2-((dimethylamino)methyl)-N-phenylaniline (24103-85-3)

Guidance literature:

With formic acid; In water; at 100 ℃; for 15h;

DOI:10.1002/ardp.19823151113

upstream raw materials:

formaldehyd

2-Methylaminomethyl-diphenylamin

1-phenyl-2,4(1H,3H)-quinazolinedione

Methyl N-phenylanthranilate

Refernces

• 1、 McGarry, Kathryn A.,Duenas, Alexi A.,Clark, Timothy B.. "Selective Formation of ortho -Aminobenzylamines by the Copper-Catalyzed Amination of Benzylamine Boronate Esters". . p. 7193 - 7204. Retrieved 2015/07/28.