Technology Process of N-[2-(benzyloxy)-5-((1R)-2-bromo-1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)phenyl]methane sulfonamide
There total 9 articles about N-[2-(benzyloxy)-5-((1R)-2-bromo-1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)phenyl]methane sulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: platinum(IV) oxide; hydrogen / tetrahydrofuran / 12 h / 20 - 25 °C / 5175.52 Torr
2: pyridine / tetrahydrofuran / 2 h / 20 °C
3: 1H-imidazole / dichloromethane / 1 h / Reflux
With
pyridine; 1H-imidazole; platinum(IV) oxide; hydrogen;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/op2001904
- Guidance literature:
-
Multi-step reaction with 5 steps
1: tetra-N-butylammonium tribromide / tetrahydrofuran; methanol / 4 h
2: borane N,N-diethylaniline complex; (1R,2S)-1-Amino-2-indanol / tetrahydrofuran / 3.5 h / 3 - 5 °C
3: platinum(IV) oxide; hydrogen / tetrahydrofuran / 12 h / 20 - 25 °C / 5175.52 Torr
4: pyridine / tetrahydrofuran / 2 h / 20 °C
5: 1H-imidazole / dichloromethane / 1 h / Reflux
With
pyridine; 1H-imidazole; platinum(IV) oxide; borane N,N-diethylaniline complex; (1R,2S)-1-Amino-2-indanol; hydrogen; tetra-N-butylammonium tribromide;
In
tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/op2001904
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C
1.2: 3 h / 20 °C / Reflux
2.1: tetra-N-butylammonium tribromide / tetrahydrofuran; methanol / 4 h
3.1: borane N,N-diethylaniline complex; (1R,2S)-1-Amino-2-indanol / tetrahydrofuran / 3.5 h / 3 - 5 °C
4.1: platinum(IV) oxide; hydrogen / tetrahydrofuran / 12 h / 20 - 25 °C / 5175.52 Torr
5.1: pyridine / tetrahydrofuran / 2 h / 20 °C
6.1: 1H-imidazole / dichloromethane / 1 h / Reflux
With
pyridine; 1H-imidazole; platinum(IV) oxide; borane N,N-diethylaniline complex; (1R,2S)-1-Amino-2-indanol; hydrogen; tetra-N-butylammonium tribromide; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/op2001904