3-hydroxyglutaramide

Base Information

• Chemical Name: 3-hydroxyglutaramide
• CAS No.: 16072-48-3
• Molecular Formula: C₅H₁₀N₂O₃
• Molecular Weight: 146.146
• Mol file: 16072-48-3.mol

Synonyms:3-hydroxyglutaramide

Chemical Property of 3-hydroxyglutaramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-hydroxyglutaramide

There total 1 articles about 3-hydroxyglutaramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

3-hydroxyglutaronitrile (13880-89-2) → 3-hydroxyglutaramide (16072-48-3) + 3-hydroxybutyric acid (158008-69-6)

Guidance literature:

With manganese(IV) oxide; silica gel; In hexane; for 168h; Ambient temperature;

DOI:10.1016/S0040-4039(00)76229-0

Reference yield:

3-hydroxyglutaramide (16072-48-3) + benzyl bromide (100-39-0) → (S)-Benzyl 3-hydroxyglutaramate + C12H15NO4

Guidance literature:

3-hydroxyglutaramide; In aq. phosphate buffer; at 30 ℃; for 7h; pH=7; Microbiological reaction;

benzyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 24h; Overall yield = 76 percent; Overall yield = 213 mg; enantioselective reaction;

Reference yield:

3-hydroxyglutaramide (16072-48-3) → 3,4,5,6-tetrachloro-pyridin-2-ylamine (51501-52-1)

Guidance literature:

With phosphorus pentachloride; Erhitzen der erhaltenen Verbindung mit Phosphorpentachlorid im Rohr auf 220-230grad;

upstream raw materials:

3-hydroxyglutaronitrile

Downstream raw materials:

3,4,5,6-tetrachloro-pyridin-2-ylamine

Refernces