5,6-diacetoxy-7-hydroxyflavone

Base Information

• Chemical Name: 5,6-diacetoxy-7-hydroxyflavone
• CAS No.: 67047-07-8
• Molecular Formula: C₁₉H₁₄O₇
• Molecular Weight: 354.316
• Mol file: 67047-07-8.mol

Synonyms:5,6-diacetoxy-7-hydroxyflavone

Chemical Property of 5,6-diacetoxy-7-hydroxyflavone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-diacetoxy-7-hydroxyflavone

There total 3 articles about 5,6-diacetoxy-7-hydroxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl triacetate (67047-05-6) → 5,6-diacetoxy-7-hydroxyflavone (67047-07-8)

Guidance literature:

With pyridine hydrochloride; silica gel; In N,N-dimethyl-formamide; at 70 - 80 ℃; for 1h; Solvent; Temperature;

Reference yield: 60.0%

7-(benzyloxy)-4-oxo-2-phenyl-4H-1-benzopyran-5,6-diyl diacetate (67047-06-7) → 5,6-diacetoxy-7-hydroxyflavone (67047-07-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetone;

Reference yield:

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one (491-67-8) → 5,6-diacetoxy-7-hydroxyflavone (67047-07-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium acetate / 80 °C

2: potassium carbonate / acetone / Reflux

3: 10 wt% Pd(OH)2 on carbon; hydrogen / tetrahydrofuran

With 10 wt% Pd(OH)2 on carbon; hydrogen; sodium acetate; potassium carbonate; In tetrahydrofuran; acetone;

DOI:10.1177/1747519820927966

upstream raw materials:

7-(benzyloxy)-4-oxo-2-phenyl-4H-1-benzopyran-5,6-diyl diacetate

4-oxo-2-phenyl-4H-1-benzopyran-5,6,7-triyl triacetate

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Downstream raw materials:

baicalin

Oroxin A

5,6-Diacetoxy-7-hydroxyflavon-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsaeure-methylester)

Refernces

• 1、 -. "Preparation method of 5,6-diacetoxy-7-hydroxyflavone". Paragraph 0025-0038. . Retrieved 2020/07/13.