methylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide

Base Information

• Chemical Name: methylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide
• CAS No.: 78175-97-0
• Molecular Formula: C₁₆H₁₉O₂P
• Molecular Weight: 274.299
• Mol file: 78175-97-0.mol

Synonyms:methylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide

Chemical Property of methylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide

There total 4 articles about methylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-phenyl-1,3,3-trimethyl-3H-2,1-benzoxaphospholium iodide → methylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide (78175-97-0)

Guidance literature:

With sodium hydrogencarbonate; In chloroform;

DOI:10.1021/ja00400a037

Reference yield:

Dichlorophenylphosphine (644-97-3) → methylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide (78175-97-0)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₃MgBr, Mg / tetrahydrofuran; diethyl ether / 1.) reflux, 3 h, 2.) room temperature, 18 h

2: 67 percent / diethyl ether / 24 h

3: 83 percent / aq. NaHCO₃ / CHCl₃

With methylmagnesium bromide; sodium hydrogencarbonate; magnesium; In tetrahydrofuran; diethyl ether; chloroform;

DOI:10.1021/ja00400a037

Reference yield:

2-(2-bromophenyl)propanol (7073-69-0) → methylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide (78175-97-0)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₃MgBr, Mg / tetrahydrofuran; diethyl ether / 1.) reflux, 3 h, 2.) room temperature, 18 h

2: 67 percent / diethyl ether / 24 h

3: 83 percent / aq. NaHCO₃ / CHCl₃

With methylmagnesium bromide; sodium hydrogencarbonate; magnesium; In tetrahydrofuran; diethyl ether; chloroform;

DOI:10.1021/ja00400a037

upstream raw materials:

Dichlorophenylphosphine

2-(2-bromophenyl)propanol

1-phenyl-3,3-dimethyl-3H-2,1-benzoxaphosphole

Refernces