2-(4-methylphenyl)-4-phenylpyrimidine

Base Information

• Chemical Name: 2-(4-methylphenyl)-4-phenylpyrimidine
• CAS No.: 77232-22-5
• Molecular Formula: C₁₇H₁₄N₂
• Molecular Weight: 246.312
• Mol file: 77232-22-5.mol

Synonyms:2-(4-methylphenyl)-4-phenylpyrimidine

Chemical Property of 2-(4-methylphenyl)-4-phenylpyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-(4-methylphenyl)-4-phenylpyrimidine

There total 14 articles about 2-(4-methylphenyl)-4-phenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(methylsulfanyl)-4-phenylpyrimidine (56734-10-2) + 4-methylphenylboronic acid (5720-05-8) → 2-(4-methylphenyl)-4-phenylpyrimidine (77232-22-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; In tetrahydrofuran; at 100 ℃; for 1h; regioselective reaction; Inert atmosphere; Microwave irradiation;

DOI:10.1055/s-0031-1290826

Reference yield: 92.0%

3-bromo-3-phenylacrylaldehyde (14804-59-2) + p-methylbenzamidine hydrochloride (6326-27-8) → 2-(4-methylphenyl)-4-phenylpyrimidine (77232-22-5)

Guidance literature:

With triethylamine; In 1,4-dioxane; Reflux; Combinatorial reaction / High throughput screening (HTS);

DOI:10.1002/hlca.201000264

Reference yield: 88.0%

p-methylbenzamidine hydrochloride (6326-27-8) + benzaldehyde (100-52-7) + triethylamine (121-44-8) → 2-(4-methylphenyl)-4-phenylpyrimidine (77232-22-5)

Guidance literature:

With di-tert-butyl peroxide; iodine; In chlorobenzene; at 150 ℃; for 8h;

DOI:10.1021/acs.orglett.0c02001

upstream raw materials:

4-chloro-6-phenyl-2-p-tolylpyrimidine

p-methylbenzamidine hydrochloride

4-hydroxy-6-phenyl-2-p-tolylpyrimidine

3-bromo-3-phenylacrylaldehyde

Refernces

• 1、 Gao, Qinghe,Wu, Manman,Zhang, Ke,Yang, Ning,Liu, Mengting,Li, Juan,Fang, Lizhen,Bai, Suping,Xu, Yongtao. "I2-Catalyzed Aerobic α,β-Dehydrogenation and Deamination of Tertiary Alkylamines: Highly Selective Synthesis of Polysubstituted Pyrimidines via Hidden Acyclic Enamines". supporting information. p. 5645 - 5649. Retrieved 2020/07/24.
• 2、 Jiang, Minhua,Nie, Quan,Cai, Mingzhong. "Heterogeneous gold(I)-catalyzed cyclization between ynals and amidines: An efficient and practical synthesis of 2,4-disubstituted pyrimidines". . p. 2488 - 2500. Retrieved 2019/07/12.