C₆₇H₉₆N₄O₁₉P₂

Base Information

• Chemical Name: C₆₇H₉₆N₄O₁₉P₂
• CAS No.: 947537-33-9
• Molecular Formula: C₆₇H₉₆N₄O₁₉P₂
• Molecular Weight: 1323.46
• Mol file: 947537-33-9.mol

Synonyms:C₆₇H₉₆N₄O₁₉P₂

Chemical Property of C₆₇H₉₆N₄O₁₉P₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₆₇H₉₆N₄O₁₉P₂

There total 7 articles about C₆₇H₉₆N₄O₁₉P₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

1-(4-(4,4-bis(diethylphosphono)butoxy)phenyl)prop-2-en-1-one (925684-96-4) + rifabutin → C67H96N4O19P2 (947537-33-9)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; at 20 ℃;

Reference yield:

Tetraethyl methylenediphosphonate (1660-94-2) → C67H96N4O19P2 (947537-33-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

1.2: 6 h / Reflux

2.1: methanol / Amberlite IR-120 / 4 h / 50 °C

3.1: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 °C

4.1: potassium carbonate / acetone / 6.5 h / Reflux

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 20 °C

With 1H-imidazole; methanol; iodine; sodium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; Amberlite IR-120; In tetrahydrofuran; dichloromethane; acetone; toluene; mineral oil;

Reference yield:

tetraethyl 4-(tetrahydro-2H-pyran-2-yloxy)butylene-1,1-bisphosphonate (150250-33-2) → C67H96N4O19P2 (947537-33-9)

Guidance literature:

Multi-step reaction with 4 steps

1: methanol / Amberlite IR-120 / 4 h / 50 °C

2: 1H-imidazole; iodine; triphenylphosphine / dichloromethane / 0 °C

3: potassium carbonate / acetone / 6.5 h / Reflux

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 20 °C

With 1H-imidazole; methanol; iodine; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; Amberlite IR-120; In dichloromethane; acetone; toluene;

upstream raw materials:

4-Hydroxyacetophenone

Tetraethyl methylenediphosphonate

1-(4-(4,4-bis(diethylphosphono)butoxy)phenyl)prop-2-en-1-one

tetraethyl 4-hydroxybutylene-1,1-bisphosphonate

Refernces