Technology Process of N-succinimidyl (2S)-2-{N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propionate
There total 17 articles about N-succinimidyl (2S)-2-{N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino}propionate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydrogencarbonate; chlorophosphoric acid diphenyl ester;
In
acetone;
at 50 ℃;
for 1h;
DOI:10.1016/S0040-4020(98)00084-2
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 28percent aq. NH3 / 168 h / Ambient temperature
3: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7
4: SOCl2
5: 43.6 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature
6: ethyl acetate; diisopropyl ether
7: 96 percent / H2 / Pd / ethanol / 3 h / 760 Torr / Ambient temperature
8: DCC / tetrahydrofuran / Ambient temperature
With
ammonium hydroxide; thionyl chloride; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide;
palladium;
In
tetrahydrofuran; ethanol; di-isopropyl ether; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm00122a003
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 28percent aq. NH3 / 168 h / Ambient temperature
3: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7
4: SOCl2
5: 27.8 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature
6: ethanolic HCl
7: 95.1 percent / H2 / Pd / ethanol / 3 h / 760 Torr / Ambient temperature
8: DCC / tetrahydrofuran / Ambient temperature
With
hydrogenchloride; ammonium hydroxide; thionyl chloride; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide;
palladium;
In
tetrahydrofuran; ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jm00122a003
