Technology Process of 7-bromo-3-amino-chroman-4-one hydrochloride
There total 7 articles about 7-bromo-3-amino-chroman-4-one hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(E,Z)-7-bromochroman-4-one O-tosyl oxime;
With
potassium ethoxide;
In
ethanol; water; toluene;
for 16h;
With
hydrogenchloride;
In
1,4-dioxane; ethanol; water; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene / 17 h / 35 - 80 °C
2.1: hydrogenchloride / dichloromethane / 0.5 h / Reflux
3.1: diisobutylaluminium hydride / n-heptane; tetrahydrofuran / 0.5 h / -78 °C
3.2: silica gel / 20 °C
4.1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 0.25 h / Reflux
5.1: triethylamine / dichloromethane / 1 h
6.1: potassium ethoxide / toluene; ethanol; water / 16 h
With
hydrogenchloride; hydroxylamine hydrochloride; potassium ethoxide; sodium acetate; diisobutylaluminium hydride; triethylamine;
In
tetrahydrofuran; ethanol; n-heptane; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydroxylamine hydrochloride; sodium acetate / ethanol; water / 0.25 h / Reflux
2: triethylamine / dichloromethane / 1 h
3: potassium ethoxide / toluene; ethanol; water / 16 h
With
hydroxylamine hydrochloride; potassium ethoxide; sodium acetate; triethylamine;
In
ethanol; dichloromethane; water; toluene;