Technology Process of Cyclopropaneacetamide, 2-(hydroxymethyl)-N,N,3,3-tetramethyl-2-propyl-, (1R,2S)-rel- (9CI)
There total 12 articles about Cyclopropaneacetamide, 2-(hydroxymethyl)-N,N,3,3-tetramethyl-2-propyl-, (1R,2S)-rel- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
collidine hydrochloride; zinc;
bis(cyclopentadienyl)titanium dichloride;
In
tetrahydrofuran;
at 20 ℃;
for 72h;
Title compound not separated from byproducts;
DOI:10.1002/chem.200400685
- Guidance literature:
-
With
collidine hydrochloride; zinc;
bis(cyclopentadienyl)titanium dichloride;
In
tetrahydrofuran;
at 20 ℃;
for 72h;
Title compound not separated from byproducts;
DOI:10.1002/chem.200400685
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: NaH / diethyl ether / 0.08 h
1.2: 90 percent / diethyl ether / 16 h / 20 °C
2.1: 92 percent / mCPBA / CH2Cl2 / 16 h / 20 °C
3.1: collidine hydrochloride; Zn / [Cp2TiCl2] / tetrahydrofuran / 72 h / 20 °C
With
collidine hydrochloride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; zinc;
bis(cyclopentadienyl)titanium dichloride;
In
tetrahydrofuran; diethyl ether; dichloromethane;
1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1002/chem.200400685