5-(4-methoxyphenyl)-4-phenylthiazole

Base Information

• Chemical Name: 5-(4-methoxyphenyl)-4-phenylthiazole
• CAS No.: 1384515-65-4
• Molecular Formula: C₁₆H₁₃NOS
• Molecular Weight: 267.351
• Mol file: 1384515-65-4.mol

Synonyms:5-(4-methoxyphenyl)-4-phenylthiazole

Chemical Property of 5-(4-methoxyphenyl)-4-phenylthiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-methoxyphenyl)-4-phenylthiazole

There total 4 articles about 5-(4-methoxyphenyl)-4-phenylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Benzyl isocyanide (88333-03-3,10340-91-7) + methyl (4-methoxyphenyl)carbodithioate (5874-09-9) → 5-(4-methoxyphenyl)-4-phenylthiazole (1384515-65-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

DOI:10.1055/s-0031-1290762

Reference yield: 75.0%

4-phenyl-thiazole (1826-12-6) + para-iodoanisole (696-62-8) → 5-(4-methoxyphenyl)-4-phenylthiazole (1384515-65-4)

Guidance literature:

With tert-Amyl alcohol; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; caesium carbonate; at 80 ℃; for 36h; regioselective reaction;

DOI:10.1039/c3sc52199k

Reference yield:

C22H17NOS → 5-(4-methoxyphenyl)-4-phenylthiazole (1384515-65-4)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / m-xylene / 40 h / 150 °C

2: palladium diacetate; caesium carbonate; tert-Amyl alcohol; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt / 36 h / 80 °C

With tert-Amyl alcohol; di-tert-butyl(methyl)phosphonium tetrafluoroborate salt; palladium diacetate; caesium carbonate; In m-xylene;

DOI:10.1039/c3sc52199k

upstream raw materials:

Benzyl isocyanide

methyl (4-methoxyphenyl)carbodithioate

4-phenyl-thiazole

para-iodoanisole

Refernces

• 1、 Lingaraju, Gejjalagere S.,Swaroop, Toreshettahally R.,Vinayaka, Ajjampura C.,Sharath Kumar, Kothanahally S.,Sadashiva, Marilinganadoddi P.,Rangappa, Kanchugarakoppal S.. "An easy access to 4,5-disubstituted thiazoles via base-induced click reaction of active methylene isocyanides with methyl dithiocarboxylates". experimental part. p. 1373 - 1379. Retrieved 2012/06/30.