isopropyl 2-(benzyloxy)-8-(bis(benzyloxy)phosphoryloxy)octanoate

Base Information

• Chemical Name: isopropyl 2-(benzyloxy)-8-(bis(benzyloxy)phosphoryloxy)octanoate
• CAS No.: 1358536-67-0
• Molecular Formula: C₃₂H₄₁O₇P
• Molecular Weight: 568.647
• Mol file: 1358536-67-0.mol

Synonyms:isopropyl 2-(benzyloxy)-8-(bis(benzyloxy)phosphoryloxy)octanoate

Chemical Property of isopropyl 2-(benzyloxy)-8-(bis(benzyloxy)phosphoryloxy)octanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isopropyl 2-(benzyloxy)-8-(bis(benzyloxy)phosphoryloxy)octanoate

There total 8 articles about isopropyl 2-(benzyloxy)-8-(bis(benzyloxy)phosphoryloxy)octanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C32H41O6P → dibenzyl hydrogen phosphite (538-60-3) + isopropyl 2-(benzyloxy)-8-(bis(benzyloxy)phosphoryloxy)octanoate (1358536-67-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.12.025

Reference yield:

6-[(tert-butyldimethylsilyl)oxy]hexanal (118794-69-7) → isopropyl 2-(benzyloxy)-8-(bis(benzyloxy)phosphoryloxy)octanoate (1358536-67-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium isopropoxide / diethyl ether; isopropyl alcohol / 0.17 h / 0 °C / Inert atmosphere

1.2: 1.67 h / 0 °C / Inert atmosphere

2.1: sodium cyanoborohydride / isopropyl alcohol / 43 h / 70 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: potassium iodide; silver(l) oxide / dichloromethane / 9 h / 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / Inert atmosphere

5.1: 1H-tetrazole / dichloromethane / 4 h / 20 °C / Inert atmosphere

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

With 1H-tetrazole; tetrabutyl ammonium fluoride; potassium isopropoxide; sodium cyanoborohydride; 3-chloro-benzenecarboperoxoic acid; potassium iodide; silver(l) oxide; In tetrahydrofuran; diethyl ether; dichloromethane; isopropyl alcohol; 1.2: Darzens condensation;

DOI:10.1016/j.bmcl.2011.12.025

Reference yield:

C17H33ClO4Si (1358536-50-1) → isopropyl 2-(benzyloxy)-8-(bis(benzyloxy)phosphoryloxy)octanoate (1358536-67-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium cyanoborohydride / isopropyl alcohol / 43 h / 70 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: potassium iodide; silver(l) oxide / dichloromethane / 9 h / 20 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / Inert atmosphere

4.1: 1H-tetrazole / dichloromethane / 4 h / 20 °C / Inert atmosphere

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 0 °C / Inert atmosphere

With 1H-tetrazole; tetrabutyl ammonium fluoride; sodium cyanoborohydride; 3-chloro-benzenecarboperoxoic acid; potassium iodide; silver(l) oxide; In tetrahydrofuran; dichloromethane; isopropyl alcohol;

DOI:10.1016/j.bmcl.2011.12.025

upstream raw materials:

isopropyl 2-(benzyloxy)-8-hydroxyoctanoate

Dibenzyl N,N-diisopropylphosphoramidite

C₁₇H₃₃ClO₄Si

isopropyl 8-(tert-butyldimethylsilyloxy)-2-hydroxyoctanoate

Refernces