Vitamin E benzyl ether

Base Information

• Chemical Name: Vitamin E benzyl ether
• CAS No.: 59965-06-9
• Molecular Formula: C₃₆H₅₆O₂
• Molecular Weight: 520.839
• Mol file: 59965-06-9.mol

Synonyms:Vitamin E benzyl ether

Chemical Property of Vitamin E benzyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Vitamin E benzyl ether

There total 20 articles about Vitamin E benzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ethanol p-toluenesulfonate (59965-21-8) + C14H29BrMg → Vitamin E benzyl ether (59965-06-9)

Guidance literature:

dilithium tetrachlorocuprate;

DOI:10.1002/hlca.19810640422

Reference yield: 62.0%

C37H56O4 (1228359-93-0) → Vitamin E benzyl ether (59965-06-9)

Guidance literature:

With triethylsilane; palladium diacetate; 2,2-dimethylpropanoic anhydride; 1,4-di(diphenylphosphino)-butane; In toluene; at 160 ℃; for 15h; chemoselective reaction;

DOI:10.1039/c9sc00892f

Reference yield:

(2S,4'R,8'R)-2',5',11'-α-tocotrienol benzyl ether (162810-67-5) → Vitamin E benzyl ether (59965-06-9)

Guidance literature:

With hydrogen; platinum on activated charcoal; In ethyl acetate; at 8 ℃; under 25857.4 Torr;

upstream raw materials:

(S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ethanol p-toluenesulfonate

(2S,4'R,8'R)-2',5',11'-α-tocotrienol benzyl ether

(-)-(S)-methyl(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)acetate

(2S)-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-yl)acetic acid methyl ester

Downstream raw materials:

Tocopherol

RRR-α-tocopheryl acetate

Refernces

• 1、 Coffen, David L.,Cohen, Noal,Pico, Anthony M.,Schmid, Rudolph,Sebastian, Mark J.,Wong, Frederick. "A MICROBIAL LIPASE BASED STEREOSELECTIVE SYNTHESIS OF (d)-α-TOCOPHEROL FROM (R)-CITRONELLAL AND (S)-(6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-YL)ACETIC ACID". . p. 527 - 552. Retrieved 2007/10/02.
• 2、 -. "2-(trimethyl-tridecenyl)-tetramethylchroman intermediates for vitamin E". . . Retrieved 2008/06/13.