2-{2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy}acetaldehyde diethylacetal

Base Information

• Chemical Name: 2-{2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy}acetaldehyde diethylacetal
• CAS No.: 290362-10-6
• Molecular Formula: C₂₅H₃₅ClN₂O₃
• Molecular Weight: 447.017
• Mol file: 290362-10-6.mol

Synonyms:2-{2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy}acetaldehyde diethylacetal

Chemical Property of 2-{2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy}acetaldehyde diethylacetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-{2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy}acetaldehyde diethylacetal

There total 1 articles about 2-{2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy}acetaldehyde diethylacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol (109806-71-5) + Bromoacetaldehyde diethyl acetal (2032-35-1) → 2-{2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy}acetaldehyde diethylacetal (290362-10-6)

Guidance literature:

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol; With sodium hydride; In tetrahydrofuran; at 50 ℃; for 0.333333h;

Bromoacetaldehyde diethyl acetal; In tetrahydrofuran; at 50 - 90 ℃; for 10h;

With water; In tetrahydrofuran;

Reference yield: 85.3%

2-{2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy}acetaldehyde diethylacetal (290362-10-6) → cetirizine (83881-51-0)

Guidance literature:

2-{2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy}acetaldehyde diethylacetal; With hydrogenchloride; In water; at 60 ℃; for 0.5h;

With sodium hydroxide; dihydrogen peroxide; In ethanol; water; at 20 ℃; pH=6.5 - 7;

Reference yield: 78.0%

2-{2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy}acetaldehyde diethylacetal (290362-10-6) → 2-{2-[4-{(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy}acetaldehyde dihydrochloride

Guidance literature:

With hydrogenchloride; In water; at 50 ℃; for 0.333333h;

upstream raw materials:

2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol

Bromoacetaldehyde diethyl acetal

Downstream raw materials:

cetirizine

Refernces