Diethyl Ethyl-d5-phenylMalonate

Base Information

• Chemical Name: Diethyl Ethyl-d5-phenylMalonate
• CAS No.: 73738-03-1
• Molecular Formula: C₁₅H₂₀O₄
• Molecular Weight: 269.282
• Mol file: 73738-03-1.mol

Synonyms:Ethyl-d⁽⁵⁾-phenylmalonsaeurediethylester

Chemical Property of Diethyl Ethyl-d5-phenylMalonate

Chemical Property:

Purity/Quality:

DiethylEthyl-d5-phenylmalonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Diethyl Ethyl-d5-phenylmalonate is the labeled analogue of Diethyl Ethylphenylmalonate (D444455), which is used in the synthesis of Barbital (B118500) and barbiturate compounds displaying pharmacological properties.

Technology Process of Diethyl Ethyl-d5-phenylMalonate

There total 2 articles about Diethyl Ethyl-d5-phenylMalonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromoethane-d5 (3675-63-6) + diethyl 2-phenylmalonate (83-13-6) → Ethyl-d(5)-phenylmalonsaeurediethylester (73738-03-1)

Guidance literature:

diethyl 2-phenylmalonate; With sodium ethanolate; In ethanol; at 0 ℃; for 1h;

bromoethane-d5; In ethanol; at 20 ℃; for 5h;

Reference yield:

→ Ethyl-d(5)-phenylmalonsaeurediethylester (73738-03-1)

Guidance literature:

Phenylmalonsaeurediethylester, d(5)-Ethylbromid;

DOI:10.1002/jlcr.2580160505

Reference yield:

Ethyl-d(5)-phenylmalonsaeurediethylester (73738-03-1) + urea (57-13-6) → Phenobarbital-ethyl-d(5) (73738-05-3)

Guidance literature:

Ethyl-d⁽⁵⁾-phenylmalonsaeurediethylester; urea; With sodium ethanolate; In ethanol; for 1h; Reflux;

With hydrogenchloride; In water; pH=2;

upstream raw materials:

bromoethane-d5

diethyl 2-phenylmalonate

Downstream raw materials:

Phenobarbital-ethyl-d⁽⁵⁾

Refernces