Technology Process of N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide
There total 1 articles about N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
O-benzylhydoxylamine hydrochloride;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
9-benzyloxy-3,3-dimethyl-1,5-dihydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxylic acid methyl ester;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
- Guidance literature:
-
N,9-bis(benzyloxy)-3,3-dimethyl-1,5-dibydro-[1,3]dioxepino[5,6-c]pyridine-8-carboxamide;
With
formic acid;
In
tetrahydrofuran; water;
at 70 ℃;
for 2h;
With
sodium hydrogencarbonate;
In
tetrahydrofuran; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: formic acid / tetrahydrofuran; water / 2 h / 70 °C
2: manganese(IV) oxide / dichloromethane / 20 °C
3: N,N-dimethyl-formamide / 2 h / 90 °C
4: hydrogen / palladium 10% on activated carbon / methanol / 1 h
With
manganese(IV) oxide; formic acid; hydrogen;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;