6-Bromoisoquinolin-3-amine

Base Information

• Chemical Name: 6-Bromoisoquinolin-3-amine
• CAS No.: 891785-28-7
• Molecular Formula: C9H7BrN2
• Molecular Weight: 223.072
• Hs Code.: 2933499090
• Mol file: 891785-28-7.mol

Synonyms:6-Bromoisoquinolin-3-amine;

Chemical Property of 6-Bromoisoquinolin-3-amine

Chemical Property:

• Vapor Pressure: 3.26E-06mmHg at 25°C
• Refractive Index: 1.732
• Boiling Point: 387.6 °C at 760 mmHg
• PKA: 4.49±0.38(Predicted)
• Flash Point: 188.2 °C
• PSA: 38.91000
• Density: 1.649 g/cm³
• LogP: 3.16070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Bromoisoquinolin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Bromoisoquinolin-3-amine is employed in the comprehensive structure-activity relationship studies to identify the allosteric inhibitors that exhibit selective recognition of protein arginine methyltransferase PRMT3 in human cells.

Technology Process of 6-Bromoisoquinolin-3-amine

There total 6 articles about 6-Bromoisoquinolin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,6-dibromoisoquinolin-3-amine (925672-85-1) → 6-bromo-isoquinolin-3-ylamine (891785-28-7)

Guidance literature:

With ammonium formate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 50 ℃; for 96h; Sealed tube;

Reference yield: 66.0%

benzyl-(6-bromo-isoquinolin-3-yl)-amine (934343-53-0) → 6-bromo-isoquinolin-3-ylamine (891785-28-7)

Guidance literature:

With trifluoroacetic acid; Heating;

DOI:10.1016/j.bmcl.2006.03.041

Reference yield: 40.0%

N-(4-bromo-benzyl)-2,2-diethoxy-acetamidine (956100-48-4) → 6-bromo-isoquinolin-3-ylamine (891785-28-7)

Guidance literature:

With sulfuric acid; at 40 ℃; for 14h;

upstream raw materials:

benzyl-(6-bromo-isoquinolin-3-yl)-amine

N-(4-bromo-benzyl)-2,2-diethoxy-acetamidine

6-bromo-3-chloro-isoquinoline

1,6-dibromoisoquinolin-3-amine

Downstream raw materials:

6-methoxy-isoquinolin-3-ylamine

Refernces

• 1、 -. "Α 7 as intranuclear hydroxynicotinic acetylcholine receptor quinuclidines compd.". Paragraph 0590; 0592. . Retrieved 2018/10/03.
• 2、 -. "ANTIBACTERIAL ISOQUINOLIN-3-YLUREA DERIVATIVES". Page/Page column 108. . Retrieved 2011/10/13.