3-(4-bromophenyl)-3-oxopropanoic acid

Base Information

• Chemical Name: 3-(4-bromophenyl)-3-oxopropanoic acid
• CAS No.: 64929-35-7
• Molecular Formula: C₉H₇BrO₃
• Molecular Weight: 243.057
• Mol file: 64929-35-7.mol

Synonyms:3-(4-bromophenyl)-3-oxopropanoic acid

Chemical Property of 3-(4-bromophenyl)-3-oxopropanoic acid

Chemical Property:

• Melting Point: 123-125 °C
• Boiling Point: 420.8±30.0 °C(Predicted)
• Density: 1.639±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-bromophenyl)-3-oxopropanoic acid

There total 9 articles about 3-(4-bromophenyl)-3-oxopropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

ethyl 4-Bromobenzoylacetate (26510-95-2) → 3-(4-bromophenyl)-3-oxopropanoic acid (64929-35-7)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃;

DOI:10.1007/s00706-016-1851-2

Reference yield:

methyl 3-(4-bromophenyl)-3-oxopropanoate (126629-81-0) → 3-(4-bromophenyl)-3-oxopropanoic acid (64929-35-7)

Guidance literature:

With sodium hydroxide; for 12h;

DOI:10.1002/cjoc.201700271

Reference yield:

3-(4-bromophenyl)-2-propynoic acid (25294-65-9) → 3-(4-bromophenyl)-3-oxopropanoic acid (64929-35-7)

Guidance literature:

With sulfuric acid; Eintragen des Reaktionsgemisches in Eis;

DOI:10.1021/ja01854a051

upstream raw materials:

3-(4-bromophenyl)-2-propynoic acid

methyl magnesium carbonate

para-bromoacetophenone

trans-4-bromocinnamic acid

Downstream raw materials:

methyl 3-(4-bromophenyl)-3-oxopropanoate

para-bromoacetophenone

(S)-1-(4-bromophenyl)-4-nitro-3-phenylbutan-1-one

(S)-3-benzyl-3-(2-(4-bromophenyl)-2-oxoethyl)indolin-2-one

Refernces

• 1、 Galman, James L.,Slabu, Iustina,Parmeggiani, Fabio,Turner, Nicholas J.. "Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction". supporting information. p. 11316 - 11319. Retrieved 2018/10/24.
• 2、 Xu, Xiaolan,Chen, Huanhuan,He, Jianbo,Xu, Huajian. "Copper-Catalysed Decarboxylative Trifluoromethylation of β-Ketoacids". supporting information. p. 1665 - 1668. Retrieved 2017/10/05.