Technology Process of 6α-hydroxy-6β-phenyl-8-azabicyclo<3.2.1>octane
There total 6 articles about 6α-hydroxy-6β-phenyl-8-azabicyclo<3.2.1>octane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium acetate, HCl, K2CO3 / H2O / 48 h / Ambient temperature; pH=4-5
2: hydrazine hydrate / ethanol / 3 h / 120 °C
3: KOH / 130 degC, 1 h; 160 degC, 2 h; 190 degC, 1.5 h
4: 48 percent / chromium trioxide / acetic acid / 70-80 degC, 16 h; 100 degC, 2 h
5: tetrahydrofuran / 6 h / Heating
6: 1.) trichloroethyl chloroformate, K2CO3; 2.) acetic acid, zinc / 1.) toluene, 2 d, reflux; 2.) water, 16 h, room temperature
With
chromium(VI) oxide; hydrogenchloride; potassium hydroxide; trichloroethyl chloroformate; sodium acetate; potassium carbonate; hydrazine hydrate; acetic acid; zinc;
In
tetrahydrofuran; ethanol; water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrahydrofuran / 6 h / Heating
2: 1.) trichloroethyl chloroformate, K2CO3; 2.) acetic acid, zinc / 1.) toluene, 2 d, reflux; 2.) water, 16 h, room temperature
With
trichloroethyl chloroformate; potassium carbonate; acetic acid; zinc;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 48 percent / chromium trioxide / acetic acid / 70-80 degC, 16 h; 100 degC, 2 h
2: tetrahydrofuran / 6 h / Heating
3: 1.) trichloroethyl chloroformate, K2CO3; 2.) acetic acid, zinc / 1.) toluene, 2 d, reflux; 2.) water, 16 h, room temperature
With
chromium(VI) oxide; trichloroethyl chloroformate; potassium carbonate; acetic acid; zinc;
In
tetrahydrofuran; acetic acid;