4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid methyl ester

Base Information

• Chemical Name: 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid methyl ester
• CAS No.: 1455093-50-1
• Molecular Formula: C₂₃H₂₁N₃O₆
• Molecular Weight: 435.436
• Mol file: 1455093-50-1.mol

Synonyms:4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid methyl ester

Chemical Property of 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid methyl ester

There total 3 articles about 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-methyl 4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)-2-hydroxybutanoate (1455129-05-1) + methyl iodide (74-88-4) → 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid methyl ester (1455093-50-1)

Guidance literature:

(S)-methyl 4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)-2-hydroxybutanoate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.05h;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

(S)-4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)-2-hydroxybutanoic acid (1455088-71-7) → 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid methyl ester (1455093-50-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.05 h / 0 °C

2.2: 0 - 20 °C

With thionyl chloride; sodium hydride; In N,N-dimethyl-formamide;

Reference yield:

1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester (1455091-23-2) → 4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid methyl ester (1455093-50-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 1 h / 120 °C

2.1: thionyl chloride / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.05 h / 0 °C

3.2: 0 - 20 °C

With thionyl chloride; sodium methylate; sodium hydride; In methanol; N,N-dimethyl-formamide;

upstream raw materials:

(S)-4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)-2-hydroxybutanoic acid

(S)-methyl 4-(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxamido)-2-hydroxybutanoate

methyl iodide

1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester

Downstream raw materials:

4-[(1-cyano-4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2-(S)-methoxybutyric acid

Refernces