7-Amino-5-chloro-2(3H)-benzoxazolone

Base Information

• Chemical Name: 7-Amino-5-chloro-2(3H)-benzoxazolone
• CAS No.: 889884-60-0
• Molecular Formula: C7H5ClN2O2
• Molecular Weight: 184.582
• Mol file: 889884-60-0.mol

Synonyms:7-Amino-5-chloro-2(3H)-benzoxazolone

Chemical Property of 7-Amino-5-chloro-2(3H)-benzoxazolone

Chemical Property:

• Melting Point: >220?C (dec.)
• Refractive Index: 1.669
• PSA: 72.02000
• Density: 1.586 g/cm³
• LogP: 1.93790
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

7-Amino-5-chloro-2(3H)-benzoxazolone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 7-Amino-5-chloro-2(3H)-benzoxazolone is an intermediate in the synthesis of Bifeprunox, which is used as an antipsychotic compound.

Technology Process of 7-Amino-5-chloro-2(3H)-benzoxazolone

There total 1 articles about 7-Amino-5-chloro-2(3H)-benzoxazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-chloro-7-nitrobenzo[d]oxazol-2(3H)-one (811810-67-0) → C7H5ClN2O2 (889884-60-0)

Guidance literature:

With hydrogen; Raney nickel; In tetrahydrofuran; methanol; at 20 ℃; for 25h; under 760.051 Torr;

Reference yield:

C7H5ClN2O2 (889884-60-0) + N,N-bis(chloro-2-ethyl)amine (334-22-5) → C11H12ClN3O2 (889884-61-1)

Guidance literature:

In chlorobenzene; for 48h; Heating / reflux;

upstream raw materials:

5-chloro-7-nitrobenzo[d]oxazol-2(3H)-one

Downstream raw materials:

C₁₁H₁₂ClN₃O₂

Refernces