2-CF₃-dihydroergotamine

Base Information

• Chemical Name: 2-CF₃-dihydroergotamine
• CAS No.: 1416417-27-0
• Molecular Formula: C₃₄H₃₆F₃N₅O₅
• Molecular Weight: 651.686
• Mol file: 1416417-27-0.mol

Synonyms:2-CF₃-dihydroergotamine

Chemical Property of 2-CF₃-dihydroergotamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-CF₃-dihydroergotamine

There total 2 articles about 2-CF₃-dihydroergotamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Togni's reagent (887144-97-0) + dihydroergotamine mesylate (6190-39-2) → 2-CF3-dihydroergotamine (1416417-27-0)

Guidance literature:

dihydroergotamine mesylate; With triethylamine; In dimethyl sulfoxide; at 20 ℃; for 0.0833333h;

Togni's reagent; With copper (I) acetate; In dimethyl sulfoxide; at 20 ℃;

Reference yield: 77.0%

iodotrifluoromethane (2314-97-8,263005-66-9) + 9,10-dihydroergotamine (511-12-6) → 2-CF3-dihydroergotamine (1416417-27-0)

Guidance literature:

9,10-dihydroergotamine; With ammonia; sodium; In ethanol; water; at -78 - -33 ℃; for 0.916667h; Inert atmosphere;

iodotrifluoromethane; In ethanol; water; at -78 - -33 ℃; for 14h;

With ammonium bicarbonate; In ethanol; water; at -78 ℃; for 1h;

upstream raw materials:

iodotrifluoromethane

9,10-dihydroergotamine

Togni's reagent

dihydroergotamine mesylate

Refernces

• 1、 -. "NOVEL FLUOROERGOLINE ANALOGS". Page/Page column 20-21. . Retrieved 2013/02/28.