chloroxoacetic acid (4-nitrophenyl)methyl ester

Base Information

• Chemical Name: chloroxoacetic acid (4-nitrophenyl)methyl ester
• CAS No.: 81779-73-9
• Molecular Formula: C₉H₆ClNO₅
• Molecular Weight: 243.603
• Mol file: 81779-73-9.mol

Synonyms:chloroxoacetic acid (4-nitrophenyl)methyl ester

Chemical Property of chloroxoacetic acid (4-nitrophenyl)methyl ester

Chemical Property:

• Boiling Point: 183 °C(Press: 11-12 Torr)
• Density: 1.498±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of chloroxoacetic acid (4-nitrophenyl)methyl ester

There total 2 articles about chloroxoacetic acid (4-nitrophenyl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitrobenzyl chloride (619-73-8) → chloroxoacetic acid (4-nitrophenyl)methyl ester (81779-73-9)

Guidance literature:

In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; oxalyl dichloride; dichloromethane;

Reference yield:

oxalyl dichloride (79-37-8) + 4-nitrobenzyl chloride (619-73-8) → chloroxoacetic acid (4-nitrophenyl)methyl ester (81779-73-9)

Guidance literature:

With chloroform;

Reference yield: 100.0%

chloroxoacetic acid (4-nitrophenyl)methyl ester (81779-73-9) + (3S,4R)-3-<(1R)-1-tert-butyldimethylsilyloxyethyl>-4-<<(2-fluoroethylthio)thiocarbonyl>thio>azetidin-2-one (85905-08-4) → [(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(2-fluoro-ethylsulfanylthiocarbonylsulfanyl)-4-oxo-azetidin-1-yl]-oxo-acetic acid 4-nitro-benzyl ester (92411-47-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 5 ℃;

upstream raw materials:

oxalyl dichloride

4-nitrobenzyl chloride

Downstream raw materials:

2-[(4-nitrobenzyl)sulfanyl]pyridine

(2-acetylsulfanyl-4-oxo-azetidin-1-yl)-oxo-acetic acid 4-nitro-benzyl ester

{(2R,3S)-2-Allyl-3-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-1-yl}-oxo-acetic acid 4-nitro-benzyl ester

[(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-(2-fluoro-ethylsulfanylthiocarbonylsulfanyl)-4-oxo-azetidin-1-yl]-oxo-acetic acid 4-nitro-benzyl ester

Refernces

• 1、 Togo, Hideo,Fujii, Misa,Yokoyama, Masataka. "Conversion of Hydroxyl Groups in Alcohols to Other Functional Groups with N-Hydroxy-2-thiopyridone, and Its Application to Dialkylamines and Thiols". . p. 57 - 67. Retrieved 2007/10/02.