C₁₉H₂₂N₂F₂

Base Information

• Chemical Name: C₁₉H₂₂N₂F₂
• CAS No.: 915953-67-2
• Molecular Formula: C₁₉H₂₂F₂N₂
• Molecular Weight: 316.394
• Mol file: 915953-67-2.mol

Synonyms:C₁₉H₂₂N₂F₂

Chemical Property of C₁₉H₂₂N₂F₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₂N₂F₂

There total 2 articles about C₁₉H₂₂N₂F₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-(dimethylamino)-1-(3-fluorobenzene)-1-propanol (915954-07-3) + 6-fluoroindoline (2343-23-9) → C19H22N2F2 (915953-67-2)

Guidance literature:

3-(dimethylamino)-1-(3-fluorobenzene)-1-propanol; With methanesulfonyl chloride; triethylamine; In acetonitrile; at 20 ℃; for 3h;

6-fluoroindoline; With potassium carbonate; at 20 ℃; for 14h; Further stages.;

DOI:10.1016/j.bmc.2006.08.039

Reference yield:

3-(dimethylamino)-1-(3-fluorophenyl)-1-propanone hydrochloride → C19H22N2F2 (915953-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 92 percent / sodium borohydride / H₂O / 2 h / 20 °C

2.1: triethylamine; methanesulfonyl chloride / acetonitrile / 3 h / 20 °C

2.2: 75 percent / potassium carbonate / 14 h / 20 °C

With sodium tetrahydroborate; methanesulfonyl chloride; triethylamine; In water; acetonitrile;

DOI:10.1016/j.bmc.2006.08.039

Reference yield: 83.0%

C19H22N2F2 (915953-67-2) → C19H20N2F2 (915953-76-3)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 0.5h; Heating;

DOI:10.1016/j.bmc.2006.08.039

upstream raw materials:

3-(dimethylamino)-1-(3-fluorobenzene)-1-propanol

6-fluoroindoline

Downstream raw materials:

C₁₉H₂₀N₂F₂

C₁₈H₁₈F₂N₂

Refernces