Technology Process of (R)-7-(benzyloxy)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline
There total 10 articles about (R)-7-(benzyloxy)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
methanol; water;
at 0 - 20 ℃;
DOI:10.1248/cpb.c12-00820
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / benzene / 2 h / Reflux
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -80 °C
2.2: 2 h / -98 - 0 °C
3.1: toluene-4-sulfonic acid; hydrazine hydrate / ethanol / 2 h / Reflux
4.1: sodium tetrahydroborate / methanol; water / 0 - 20 °C
With
sodium tetrahydroborate; n-butyllithium; toluene-4-sulfonic acid; hydrazine hydrate;
In
tetrahydrofuran; methanol; ethanol; hexane; water; benzene;
DOI:10.1248/cpb.c12-00820
- Guidance literature:
-
Multi-step reaction with 5 steps
1: diphenyl phosphoryl azide; triethylamine / toluene / 0.5 h / 0 °C / Reflux
2: toluene / 1 h / 20 °C / Cooling with ice
3: trifluoroacetic acid / dichloromethane / 16 h / -20 °C
4: sodium butanolate / butan-1-ol / 1 h / Reflux
5: sodium tetrahydroborate / methanol; water / 1 h / 20 °C
With
sodium tetrahydroborate; diphenyl phosphoryl azide; triethylamine; sodium butanolate; trifluoroacetic acid;
In
methanol; dichloromethane; water; toluene; butan-1-ol;
1: |Curtius Rearrangement / 3: |Pictet-Spengler Synthesis;
DOI:10.3987/COM-18-S(T)64
