4-BROMO-2-TRIFLUOROMETHYLPYRIDINE

Base Information

• Chemical Name: 4-BROMO-2-TRIFLUOROMETHYLPYRIDINE
• CAS No.: 887583-90-6
• Molecular Formula: C6H3BrF3N
• Molecular Weight: 225.996
• Hs Code.: 2933399090
• Mol file: 887583-90-6.mol

Synonyms:4-Bromo-2-(trifluoromethyl)pyridine;2-(Trifluoromethyl)-4-bromopyridine;

Chemical Property of 4-BROMO-2-TRIFLUOROMETHYLPYRIDINE

Chemical Property:

• Vapor Pressure: 2.248mmHg at 25°C
• Refractive Index: 1.471
• Boiling Point: 167.399 °C at 760 mmHg
• PKA: -1.23±0.10(Predicted)
• Flash Point: 55.042 °C
• PSA: 12.89000
• Density: 1.707 g/cm³
• LogP: 2.86290
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98% ^*data from raw suppliers

4-Bromo-2-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-2-TRIFLUOROMETHYLPYRIDINE

There total 2 articles about 4-BROMO-2-TRIFLUOROMETHYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

→ 4-bromo-2-(trifluoromethyl)pyridine (887583-90-6)

Guidance literature:

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; copper(l) iodide; at 50 ℃; for 24h; Inert atmosphere;

Reference yield: 38.0%

2-(trifluoromethyl)pyridin-4-amine (147149-98-2) → 4-bromo-2-(trifluoromethyl)pyridine (887583-90-6)

Guidance literature:

2-(trifluoromethyl)pyridin-4-amine; With Bromotrichloromethane; sodium nitrite; In dichloromethane; water; at 23 ℃; for 0.0833333h;

With acetic acid; In dichloromethane; water; at 23 ℃; for 1h;

DOI:10.1021/acs.orglett.7b00771

Reference yield: 89.0%

4-bromo-2-(trifluoromethyl)pyridine (887583-90-6) + (E)-N-((3-bromo-4-methoxyphenyl)(2-cyano-3-fluorophenyl)methylene)-2-methylpropane-2-sulfinamide (1227163-20-3) → 1-(3-Bromo-4-methoxyphenyl)-4-fluoro-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine (1227163-19-0)

Guidance literature:

4-bromo-2-(trifluoromethyl)pyridine; (E)-N-((3-bromo-4-methoxyphenyl)(2-cyano-3-fluorophenyl)methylene)-2-methylpropane-2-sulfinamide; With tert.-butyl lithium; In tetrahydrofuran; at -100 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

upstream raw materials:

2-(trifluoromethyl)pyridin-4-amine

Downstream raw materials:

N-(2-Methoxyethyl)-3-(2-[[2-(trifluoromethyl)pyridin-4-yl]methyl]-1-benzothiophen-7-yl)benzamide

1-(3-Bromo-4-methoxyphenyl)-4-fluoro-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine

6-chloro-4-fluoro-1-(3-methoxyphenyl)-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine

4-(2-Trifluoromethyl)pyridine-4-ylphenol

Refernces

• 1、 -. "Trifluorolactic demethylating agent powder, its manufacturing method using the same and method of manufacturing a trifluoromethyl group-containing compound". Paragraph 0033; 0034. . Retrieved 2017/03/14.