3-chloromethyl-1-methyl-1,2,5,6-tetrahydropyridine hydrochloride

Base Information

• Chemical Name: 3-chloromethyl-1-methyl-1,2,5,6-tetrahydropyridine hydrochloride
• CAS No.: 128721-19-7
• Molecular Formula: C₇H₁₂ClN*ClH
• Molecular Weight: 182.093
• Mol file: 128721-19-7.mol

Synonyms:3-chloromethyl-1-methyl-1,2,5,6-tetrahydropyridine hydrochloride

Chemical Property of 3-chloromethyl-1-methyl-1,2,5,6-tetrahydropyridine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-chloromethyl-1-methyl-1,2,5,6-tetrahydropyridine hydrochloride

There total 1 articles about 3-chloromethyl-1-methyl-1,2,5,6-tetrahydropyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(Hydroxymethyl)-1-methylpyridinium iodide (6457-55-2) → 3-chloromethyl-1-methyl-1,2,5,6-tetrahydropyridine hydrochloride (128721-19-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / sodium borohydride / methanol / 3 h / 0 °C

2: 79 percent / thionyl chloride / tetrahydrofuran / 2 h / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; In tetrahydrofuran; methanol;

DOI:10.3987/COM-89-5240

Reference yield:

3-chloromethyl-1-methyl-1,2,5,6-tetrahydropyridine hydrochloride (128721-19-7) → 3-<2-ethylthio-2-((1-phenylsulfonyl)-2-indolyl)ethyl>-1-methyl-1,2,5,6-tetrahydropyridine (128721-35-7)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / tetrahydrofuran / -40 °C

2: 1.) n-butyllithium / 1.) THF, -40 deg C, 20 min, 2.) 1 h

With n-butyllithium; In tetrahydrofuran;

DOI:10.3987/COM-89-5240

Reference yield:

3-chloromethyl-1-methyl-1,2,5,6-tetrahydropyridine hydrochloride (128721-19-7) → 2-<2-(1-methyl-1,2,5,6-tetrahydro-3-pyridylmethyl)-1,3-dithian-2-yl>-1-(4-methoxyphenylsulfonyl)indole (128721-23-3)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / tetrahydrofuran / -40 °C

2: 1.) n-butyllithium / 1.) THF, -40 deg C, 15 min, 2.) -40 deg C, 1 h

With n-butyllithium; In tetrahydrofuran;

DOI:10.3987/COM-89-5240

upstream raw materials:

3-(Hydroxymethyl)-1-methylpyridinium iodide

Downstream raw materials:

3-<2-ethylthio-2-((1-phenylsulfonyl)-2-indolyl)ethyl>-1-methyl-1,2,5,6-tetrahydropyridine

2-<2-(1-methyl-1,2,5,6-tetrahydro-3-pyridylmethyl)-1,3-dithian-2-yl>-1-(4-methoxyphenylsulfonyl)indole

Refernces