hex-2-en-4-yne-1,6-diol

Base Information

• Chemical Name: hex-2-en-4-yne-1,6-diol
• CAS No.: 860255-95-4
• Molecular Formula: C₆H₈O₂
• Molecular Weight: 112.128
• Mol file: 860255-95-4.mol

Synonyms:hex-2-en-4-yne-1,6-diol

Chemical Property of hex-2-en-4-yne-1,6-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hex-2-en-4-yne-1,6-diol

There total 5 articles about hex-2-en-4-yne-1,6-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

propargyl alcohol (107-19-7) + phenylacetylene (536-74-3) → hex-2-en-4-yne-1,6-diol (860255-95-4) + (E)-5-phenyl-penta-2-ene-4-yne-1-ol (17733-79-8,129593-48-2,40317-08-6)

Guidance literature:

With 2-(hydroxymethyl)-2-methylpropane-1,3-diol; [Pd(μ-κ²-O,O-OAc)(κ²-C,P-(t-Bu)₂PCH₂C(Me)₂CH₂)]₂; In acetonitrile; at 24 ℃; for 24h;

DOI:10.1021/acscatal.6b01541

Reference yield:

propargyl alcohol (107-19-7) + phenylacetylene (536-74-3) → hex-2-en-4-yne-1,6-diol (860255-95-4) + 5-phenyl-2-penten-4-yn-1-ol (17733-79-8) + 4-methylenepent-2-yne-1,5-diol

Guidance literature:

With [Pd(μ-κ²-O,O-OAc)(κ²-C,P-(t-Bu)₂PCH₂C(Me)₂CH₂)]₂; In acetonitrile; at 24 ℃; for 17h;

DOI:10.1021/acscatal.6b01541

Reference yield:

propargyl alcohol (107-19-7) + phenylacetylene (536-74-3) → hex-2-en-4-yne-1,6-diol (860255-95-4) + 1,4-diphenylbut-3-en-1-yne (13343-78-7,13343-79-8,13141-45-2) + 5-phenyl-2-penten-4-yn-1-ol (17733-79-8)

Guidance literature:

With [Pd(μ-κ²-O,O-OAc)(κ²-C,P-(t-Bu)₂PCH₂C(Me)₂CH₂)]₂; potassium carbonate; In acetonitrile; at 24 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acscatal.6b01541

upstream raw materials:

propargyl alcohol

phenylacetylene

Downstream raw materials:

1,6-hexanediol

1,6-bis(N-phenylcarbamoyl)hexane

Refernces