(phenyl)(2-phenylquinolin-3-yl)methanone

Base Information

• Chemical Name: (phenyl)(2-phenylquinolin-3-yl)methanone
• CAS No.: 113059-25-9
• Molecular Formula: C₂₂H₁₅NO
• Molecular Weight: 309.367
• Mol file: 113059-25-9.mol

Synonyms:(phenyl)(2-phenylquinolin-3-yl)methanone

Chemical Property of (phenyl)(2-phenylquinolin-3-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (phenyl)(2-phenylquinolin-3-yl)methanone

There total 33 articles about (phenyl)(2-phenylquinolin-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-azidobenzaldehyde (16714-25-3) + 1,3-diphenylpropanedione (120-46-7,61346-73-4) → (phenyl)(2-phenylquinolin-3-yl)methanone (113059-25-9)

Guidance literature:

With diethylamine; triphenylphosphine; In acetonitrile; at 95 ℃; for 6h;

DOI:10.1039/c8gc03180k

Reference yield: 91.0%

1,3-diphenylpropanedione (120-46-7,61346-73-4) + 2-nitro-benzaldehyde (552-89-6) → (phenyl)(2-phenylquinolin-3-yl)methanone (113059-25-9)

Guidance literature:

With iron; acetic acid; at 50 ℃; for 1h;

DOI:10.1039/c4ra06410k

Reference yield: 89.0%

1,3-diphenylpropanedione (120-46-7,61346-73-4) + ortho-bromobenzaldehyde (6630-33-7) → (phenyl)(2-phenylquinolin-3-yl)methanone (113059-25-9)

Guidance literature:

With D-glucose; copper(II) sulfate; L-proline; potassium hydroxide; In ethanol; water; at 90 ℃; for 4h;

DOI:10.1039/c4ra14138e

upstream raw materials:

3-benzoyl-2-phenyl-quinoline-4-carboxylic acid

(Z)-3-hydroxy-1,3-diphenyl-2-propen-1-one

o-aminobenzaldehyde

1,3-diphenylpropanedione

Downstream raw materials:

2-Phenylquinoline

benzoic acid

Refernces

• 1、 Trofimov,Belyaeva,Nikitina,Mal'Kina,Afonin,Ushakov,Vashchenko. "Transition metal-free one-pot double C-H functionalization of quinolines with disubstituted electron-deficient acetylenes". . p. 5863 - 5866. Retrieved 2018.
• 2、 Liu, Yuan,Wang, Chen,Tong, Yixin,Ling, Yong,Zhou, Changjian,Xiong, Biao. "Cascade Reaction of α, β-Unsaturated Ketones and 2-Aminoaryl Alcohols for the Synthesis of 3-Acylquinolines by a Copper Nanocatalyst". supporting information. p. 4422 - 4429. Retrieved 2021/08/07.
• 3、 Zhang, Xiaofeng,Ma, Xiaoming,Qiu, Weiqi,Evans, Jason,Zhang, Wei. "Cascade Knoevenagel and aza-Wittig reactions for the synthesis of substituted quinolines and quinolin-4-ols". supporting information. p. 349 - 354. Retrieved 2019/01/28.