2,5-dimethyl-4-phenyl-3-<1-oxo-3-(4-amino-3-nitrophenyl)-2-propenyl>furan

Base Information

• Chemical Name: 2,5-dimethyl-4-phenyl-3-<1-oxo-3-(4-amino-3-nitrophenyl)-2-propenyl>furan
• CAS No.: 104406-10-2
• Molecular Formula: C₂₁H₁₈N₂O₄
• Molecular Weight: 362.385
• Mol file: 104406-10-2.mol

Synonyms:2,5-dimethyl-4-phenyl-3-<1-oxo-3-(4-amino-3-nitrophenyl)-2-propenyl>furan

Chemical Property of 2,5-dimethyl-4-phenyl-3-<1-oxo-3-(4-amino-3-nitrophenyl)-2-propenyl>furan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dimethyl-4-phenyl-3-<1-oxo-3-(4-amino-3-nitrophenyl)-2-propenyl>furan

There total 1 articles about 2,5-dimethyl-4-phenyl-3-<1-oxo-3-(4-amino-3-nitrophenyl)-2-propenyl>furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-amino-3-nitro-benzaldehyde (51818-99-6) + 1-(2,5-Dimethyl-4-phenylfuran-3-yl)-1-ethanone (88484-88-2) → 2,5-dimethyl-4-phenyl-3-<1-oxo-3-(4-amino-3-nitrophenyl)-2-propenyl>furan (104406-10-2)

Guidance literature:

With sodium hydroxide; In ethanol; at 15 ℃; for 3h;

Reference yield:

2,5-dimethyl-4-phenyl-3-<1-oxo-3-(4-amino-3-nitrophenyl)-2-propenyl>furan (104406-10-2) → 3-(3,4-Diamino-phenyl)-1-(2,5-dimethyl-4-phenyl-furan-3-yl)-propan-1-one (104406-31-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; under 1838.8 Torr; Ambient temperature;

Reference yield:

2,5-dimethyl-4-phenyl-3-<1-oxo-3-(4-amino-3-nitrophenyl)-2-propenyl>furan (104406-10-2) → Methyl 5(6)-<3-(2,5-dimethyl-4-phenylfur-3-yl)-3-oxopropyl>benzimidazole-2-carbamate (104406-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd-C / ethanol / 1838.8 Torr / Ambient temperature

2: 1.) 25percent NaOH, 2.) gl. acetic acid / 1.) water, 10-15 deg C, till pH 7-8, 2.) pH₅, EtOH, reflux

With sodium hydroxide; hydrogen; acetic acid; palladium on activated charcoal; In ethanol;

upstream raw materials:

4-amino-3-nitro-benzaldehyde

1-(2,5-Dimethyl-4-phenylfuran-3-yl)-1-ethanone

Downstream raw materials:

3-(3,4-Diamino-phenyl)-1-(2,5-dimethyl-4-phenyl-furan-3-yl)-propan-1-one

Methyl 5(6)-<3-(2,5-dimethyl-4-phenylfur-3-yl)-3-oxopropyl>benzimidazole-2-carbamate

Refernces