C₁₈H₁₉F₂N₅O₄

Base Information

• Chemical Name: C₁₈H₁₉F₂N₅O₄
• CAS No.: 1214911-72-4
• Molecular Formula: C₁₈H₁₉F₂N₅O₄
• Molecular Weight: 407.377
• Mol file: 1214911-72-4.mol

Synonyms:C₁₈H₁₉F₂N₅O₄

Chemical Property of C₁₈H₁₉F₂N₅O₄

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₁₈H₁₉F₂N₅O₄

There total 5 articles about C₁₈H₁₉F₂N₅O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(2-nitrophenyl)acetyl chloride (22751-23-1) + 5-amino-1-(4,4-difluoro-cyclohexyl)-1H-pyrazole-4-carboxylic acid amide (1082745-54-7) → C18H19F2N5O4 (1214911-72-4)

Guidance literature:

With pyridine; dmap; In toluene; at 20 ℃; for 24h; Inert atmosphere;

Reference yield:

4,4-difluorocyclohexanone (22515-18-0) → C18H19F2N5O4 (1214911-72-4)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen / acetic acid; platinum(IV) oxide / isopropyl alcohol / 12 h / 20 °C / 2585.81 Torr

2: dichloromethane / 12 h / 20 °C

3: triethylamine / ethanol / 2 h / 50 °C

4: ammonia; dihydrogen peroxide / ethanol; water / 2.17 h / 20 °C

5: pyridine / dmap / toluene / 24 h / 20 °C / Inert atmosphere

With pyridine; ammonia; hydrogen; dihydrogen peroxide; triethylamine; dmap; platinum(IV) oxide; acetic acid; In ethanol; dichloromethane; water; isopropyl alcohol; toluene;

Reference yield:

N'-(4,4-difluorocyclohexyl)hydrazinecarboxylic acid tert-butyl ester (1214910-72-1) → C18H19F2N5O4 (1214911-72-4)

Guidance literature:

Multi-step reaction with 4 steps

1: dichloromethane / 12 h / 20 °C

2: triethylamine / ethanol / 2 h / 50 °C

3: ammonia; dihydrogen peroxide / ethanol; water / 2.17 h / 20 °C

4: pyridine / dmap / toluene / 24 h / 20 °C / Inert atmosphere

With pyridine; ammonia; dihydrogen peroxide; triethylamine; dmap; In ethanol; dichloromethane; water; toluene;

upstream raw materials:

4,4-difluorocyclohexanone

(2-nitrophenyl)acetyl chloride

5-amino-1-(4,4-difluoro-cyclohexyl)-1H-pyrazole-4-carboxylic acid amide

5-amino-1-(4,4-difluorocyclohexyl)-1H-pyrazol-4-carbonitrile

Downstream raw materials:

C₁₈H₁₉F₂N₅O*ClH

C₂₀H₁₉F₂N₇O

Refernces