Technology Process of 2-(4-Chloro-phenyl)-N-hydroxy-1-oxo-1,2-dihydro-isoquinoline-4-carboxamidine
There total 7 articles about 2-(4-Chloro-phenyl)-N-hydroxy-1-oxo-1,2-dihydro-isoquinoline-4-carboxamidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine; hydroxylamine hydrochloride; sodium carbonate;
In
ethanol;
at 100 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 91 percent / 0.25 h / Heating
2: 64 percent / NaOH / ethanol / Heating
3: SOCl2 / 2 h / Heating
4: cold liq. ammonia
5: 89 percent / SOCl2 / 2 h / Heating
6: 67 percent / hydroxylamine hydrochloride, sodium carbonate, pyridine / ethanol / 5 h / 100 °C
With
pyridine; sodium hydroxide; thionyl chloride; hydroxylamine hydrochloride; ammonia; sodium carbonate;
In
ethanol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: cold liq. ammonia
2: 89 percent / SOCl2 / 2 h / Heating
3: 67 percent / hydroxylamine hydrochloride, sodium carbonate, pyridine / ethanol / 5 h / 100 °C
With
pyridine; thionyl chloride; hydroxylamine hydrochloride; ammonia; sodium carbonate;
In
ethanol;