2-Thiazolecarboximidamide, N-hydroxy-

Base Information

• Chemical Name: 2-Thiazolecarboximidamide, N-hydroxy-
• CAS No.: 89829-62-9
• Molecular Formula: C₄H₅N₃OS
• Molecular Weight: 143.169
• Mol file: 89829-62-9.mol

Synonyms:2-Thiazolecarboxamidoxime(7CI); N'-Hydroxythiazole-2-carboximidamide

Chemical Property of 2-Thiazolecarboximidamide, N-hydroxy-

Chemical Property:

• PSA: 99.74000
• LogP: 0.93790

Purity/Quality:

99%min ^*data from raw suppliers

N-hydroxy-2-Thiazolecarboximidamide 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiazolecarboximidamide, N-hydroxy-

There total 2 articles about 2-Thiazolecarboximidamide, N-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiazole-2-carbonitrile (1452-16-0) → 1,3-thiazole-2-amidoxime (89829-62-9)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In ethanol;

Reference yield:

thiazole-2-carbonitrile (1452-16-0) → N-hydroxy-1,3-thiazole-2-carboximidamide (89829-62-9)

Guidance literature:

With hydroxylamine; In methanol; at 60 ℃;

DOI:10.1021/jm070027u

upstream raw materials:

thiazole-2-carbonitrile

Refernces

• 1、 Flipo, Marion,Desroses, Matthieu,Lecat-Guillet, Nathalie,Villemagne, Baptiste,Blondiaux, Nicolas,Leroux, Florence,Piveteau, Catherine,Mathys, Vanessa,Flament, Marie-Pierre,Siepmann, Juergen,Villeret, Vincent,Wohlk?nig, Alexandre,Wintjens, René,Soror, Sameh H.,Christophe, Thierry,Jeon, Hee Kyoung,Locht, Camille,Brodin, Priscille,Déprez, Benoit,Baulard, Alain R.,Willand, Nicolas. "Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors". experimental part. p. 68 - 83. Retrieved 2012/03/10.
• 2、 Koch, Uwe,Attenni, Barbara,Malancona, Savina,Colarusso, Stefania,Conte, Immacolata,Di Filippo, Marcello,Harper, Steven,Pacini, Barbara,Giomini, Claudia,Thomas, Steven,Incitti, Ilario,Tomei, Licia,De Francesco, Raffaele,Altamura, Sergio,Matassa, Victor G.,Narjes, Frank. "2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: Discovery, SAR, modeling, and mutagenesis". . p. 1693 - 1705. Retrieved 2007/10/03.