ethyl 3-fluoro-2-iodobenzoate

Base Information

• Chemical Name: ethyl 3-fluoro-2-iodobenzoate
• CAS No.: 389-43-5
• Molecular Formula: C₉H₈FIO₂
• Molecular Weight: 294.064
• Mol file: 389-43-5.mol

Synonyms:ethyl 3-fluoro-2-iodobenzoate

Chemical Property of ethyl 3-fluoro-2-iodobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-fluoro-2-iodobenzoate

There total 5 articles about ethyl 3-fluoro-2-iodobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-fluoro-2-iodobenzoic acid (387-48-4) + ethyl iodide (75-03-6) → ethyl 3-fluoro-2-iodobenzoate (389-43-5)

Guidance literature:

3-fluoro-2-iodobenzoic acid; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

ethyl iodide; In N,N-dimethyl-formamide; at 20 - 50 ℃;

DOI:10.1021/acs.joc.0c00542

Reference yield: 70.0%

→ ethyl 3-fluoro-2-iodobenzoate (389-43-5)

Guidance literature:

Reference yield:

2-iodo-3-nitrobenzoic acid (5398-69-6) → ethyl 3-fluoro-2-iodobenzoate (389-43-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tin (II)-chloride; aqueous hydrochloric acid; ethanol

2: aqueous hydrogen fluoride / Behandeln der erhaltenen Suspension mit Natriumnitrit

3: thionyl chloride

With hydrogenchloride; thionyl chloride; ethanol; hydrogen fluoride; tin(ll) chloride;

DOI:10.1021/ja01329a039

upstream raw materials:

ethanol

3-fluoro-2-iodobenzoic acid

2-iodo-3-nitrobenzoic acid

3-amino-2-iodo-benzoic acid

Refernces

• 1、 -. "BISAMID-ZINKBASEN". Page/Page column 7-8. . Retrieved 2010/07/04.