diethyl methyl-1 phenyl-2 ethenyl-1,2 phosphonate

Base Information

• Chemical Name: diethyl methyl-1 phenyl-2 ethenyl-1,2 phosphonate
• CAS No.: 74152-49-1
• Molecular Formula: C₁₃H₁₉O₃P
• Molecular Weight: 254.266
• Mol file: 74152-49-1.mol

Synonyms:diethyl methyl-1 phenyl-2 ethenyl-1,2 phosphonate

Chemical Property of diethyl methyl-1 phenyl-2 ethenyl-1,2 phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl methyl-1 phenyl-2 ethenyl-1,2 phosphonate

There total 16 articles about diethyl methyl-1 phenyl-2 ethenyl-1,2 phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

benzoyl chloride (98-88-4) + diethyl 2-isopropenylphosphonate (20170-34-7) → diethyl methyl-1 phenyl-2 ethenyl-1,2 phosphonate (74152-49-1)

Guidance literature:

With palladium diacetate; N,N-diethylbenzylamine; at 85 - 100 ℃; for 1.5h;

Reference yield: 78.0%

benzaldehyde (100-52-7) + C10H23O6P2(1-)*Li(1+) → diethyl methyl-1 phenyl-2 ethenyl-1,2 phosphonate (74152-49-1)

Guidance literature:

In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1016/0022-328X(86)80147-4

Reference yield: 77.0%

ethylphosphonic acid diethyl ester (78-38-6) + benzaldehyde (100-52-7) → diethyl methyl-1 phenyl-2 ethenyl-1,2 phosphonate (74152-49-1)

Guidance literature:

ethylphosphonic acid diethyl ester; With diethyl chlorophosphate; lithium diisopropyl amide; In tetrahydrofuran;

benzaldehyde; In tetrahydrofuran;

DOI:10.1021/jo034707q

upstream raw materials:

Diethyl(1-(trimethylsilyl)ethyl)phosphonate

benzaldehyde

ethylphosphonic acid diethyl ester

diethyl chlorophosphate

Refernces

• 1、 Gui, Qingwen,Hu, Liang,Chen, Xiang,Liu, Jidan,Tan, Ze. "Stereoselective synthesis of vinylphosphonates and phosphine oxides via silver-catalyzed phosphorylation of styrenes". supporting information. p. 13922 - 13924. Retrieved 2015/09/07.
• 2、 Ruiz, Maria,Fernandez, M. Carmen,Diaz, Aniana,Quintela, Jose M.,Ojea, Vicente. "Diastereoselective synthesis of 2-amino-4-phosphonobutanoic acids by conjugate addition of lithiated schoellkopf's bislactim ethers to vinylphosphonates". . p. 7634 - 7645. Retrieved 2007/10/03.