1-(2-phenylethynyl)-1-cyclobutanol

Base Information

• Chemical Name: 1-(2-phenylethynyl)-1-cyclobutanol
• CAS No.: 308805-77-8
• Molecular Formula: C₁₂H₁₂O
• Molecular Weight: 172.227
• Mol file: 308805-77-8.mol

Synonyms:1-(2-phenylethynyl)-1-cyclobutanol

Chemical Property of 1-(2-phenylethynyl)-1-cyclobutanol

Chemical Property:

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Technology Process of 1-(2-phenylethynyl)-1-cyclobutanol

There total 1 articles about 1-(2-phenylethynyl)-1-cyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

phenylethynylmagnesium bromide (6738-06-3) + cyclobutanone (1191-95-3) → 1-(2-phenylethynyl)-1-cyclobutanol (308805-77-8)

Guidance literature:

phenylethynylmagnesium bromide; With cerium(III) chloride; In tetrahydrofuran; at -78 ℃; for 1h; Schlenk technique;

cyclobutanone; In tetrahydrofuran; at -78 - 25 ℃; for 6h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201308611

Reference yield: 93.0%

C9H10FNO2 + 1-(2-phenylethynyl)-1-cyclobutanol (308805-77-8) → 3-butyryl-6-fluoro-4-phenylisoquinoline-1(2H)-one

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1080/00397911.2020.1755984

Reference yield: 92.0%

1-(2-phenylethynyl)-1-cyclobutanol (308805-77-8) → C24H22O

Guidance literature:

With silver hexafluoroantimonate; In 1,2-dichloro-ethane; at 80 ℃; for 1h;

upstream raw materials:

phenylethynylmagnesium bromide

cyclobutanone

Downstream raw materials:

2-(diphenylmethylene)cyclopentan-1-one

9-phenyl-2,3-dihydro-1H-cyclopenta[b]quinoline

Refernces