benzylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide

Base Information

• Chemical Name: benzylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide
• CAS No.: 78175-99-2
• Molecular Formula: C₂₂H₂₃O₂P
• Molecular Weight: 350.397
• Mol file: 78175-99-2.mol

Synonyms:benzylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide

Chemical Property of benzylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of benzylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide

There total 6 articles about benzylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1-benzyl-1-phenyl-3,3-dimethyl-3H-2,1-benzoxaphospholium bromide → benzylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide (78175-99-2)

Guidance literature:

With sodium hydrogencarbonate; In chloroform-d1;

DOI:10.1021/ja00400a037

Reference yield:

1-phenyl-3,3-dimethyl-3H-2,1-benzoxaphosphole (78175-94-7) → benzylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide (78175-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / diethyl ether / 24 h

2: 59 percent / sodium bicarbonate / CDCl₃

With sodium hydrogencarbonate; In diethyl ether; chloroform-d1;

DOI:10.1021/ja00400a037

Reference yield:

benzyl bromide (100-39-0) → benzylphenyl-(2-(1-methyl-1-hydroxyethyl)phenyl)phosphine oxide (78175-99-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / diethyl ether / 24 h

2: 59 percent / sodium bicarbonate / CDCl₃

With sodium hydrogencarbonate; In diethyl ether; chloroform-d1;

DOI:10.1021/ja00400a037

upstream raw materials:

benzyl bromide

Dichlorophenylphosphine

2-(2-bromophenyl)propanol

1-phenyl-3,3-dimethyl-3H-2,1-benzoxaphosphole

Downstream raw materials:

1-benzyl-1-phenyl-3,3-dimethyl-3H-2,1-benzoxaphospholium trifluoromethanesulfonate

Refernces

• 1、 Granoth, Itshak,Martin. "Stable monocyclic monoalkoxyhalophosphoranes: Possible examples of structures on the borderline between haloalkoxyphosphoranes and alkoxyphosphonium halides". . p. 2711 - 2715. Retrieved 2007/10/02.