2-Chloro-4,6-dihydroxy-3-methylpyridine

Base Information

• Chemical Name: 2-Chloro-4,6-dihydroxy-3-methylpyridine
• CAS No.: 89379-84-0
• Molecular Formula: C6H6 Cl N O2
• Molecular Weight: 159.572
• Hs Code.: 2933399090
• Mol file: 89379-84-0.mol

Synonyms:2,4-Pyridinediol,6-chloro-5-methyl- (7CI)

Chemical Property of 2-Chloro-4,6-dihydroxy-3-methylpyridine

Chemical Property:

• PSA: 53.35000
• LogP: 1.45460

Purity/Quality:

99.9% ^*data from raw suppliers

6-Chloro-4-hydroxy-5-methylpyridin-2(1H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4,6-dihydroxy-3-methylpyridine

There total 5 articles about 2-Chloro-4,6-dihydroxy-3-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

propiononitrile (107-12-0) + malonoyl dichloride (1663-67-8) → 6-Chloro-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridine (89379-84-0) + 6-Chloro-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridine hydrochloride (95306-65-3)

Guidance literature:

for 24h; Yields of byproduct given; Ambient temperature;

Reference yield: 53.0%

propiononitrile (107-12-0) + malonoyl dichloride (1663-67-8) → 6-Chloro-2,4-dihydroxy-5-methyl-pyridine (89379-84-0)

Guidance literature:

at 20 ℃; for 16h;

Reference yield: 52.0%

propiononitrile (107-12-0) + malonoyl dichloride (1663-67-8) → 6-Chloro-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridine (89379-84-0)

Guidance literature:

upstream raw materials:

propiononitrile

malonoyl dichloride

Downstream raw materials:

2-Chlor-4,6-dihydroxy-3-methyl-5-nitro-pyridin

Refernces

• 1、 Buck, Judith,Madeley, J. Paul,Pattenden, Gerald. "Lithiation of 4-Methoxy-2-pyridones. Synthetic Entry to Tenellin and Funiculosin, and Related Natural 3,5-Disubstituted 4-Oxy-2-pyridones". . p. 67 - 73. Retrieved 2007/10/02.
• 2、 Bernatek,Elvidge,Stensrud,Zaidi. "Pyrimidines from malonyl chloride and nitriles.". . p. 2048 - 2049. Retrieved 2007/10/09.